{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:54:36Z","timestamp":1790913276490,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Despite increasing use of core needle biopsy (CNB) for salivary gland lesions, its clinical utility requires further evaluation. As previous studies have focused mainly on surgically confirmed lesions, this study evaluated the diagnostic utility and reliability of CNB for major salivary gland lesions irrespective of treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 217 patients who underwent major salivary gland CNB at the Helsinki University Hospital (HUS, Helsinki, Finland) between 2020 and 2022. Patients were classified into surgical and follow\u2010up groups, with follow\u2010up data review of patient records for non\u2010operated patients through the end of 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether, 247 CNB samples were obtained from 221 major salivary gland lesions. Ninety\u2010three patients (42%) underwent surgery, and 128 tumors in 124 patients (58%) were followed up only. Based on histologically verified cases, CNB demonstrated 93.8% sensitivity and 98.5% specificity for malignancy, with one false benign and one false malignant result. No malignancies were identified in the follow\u2010up group during a minimum of 2\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CNB is a highly accurate diagnostic tool for salivary gland tumors and may facilitate the identification of lesions that can be safely managed without surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70954","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:14:45Z","timestamp":1790910885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Core Needle Biopsy in the Diagnosis of Major Salivary Gland Tumors"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3484-7417","authenticated-orcid":false,"given":"Mira","family":"Naukkarinen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Helsinki Head and Neck Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jetta","family":"Kelppe","sequence":"additional","affiliation":[{"name":"Department of Pathology HUSLAB, Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susa","family":"Saarinen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Helsinki Head and Neck Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-5237","authenticated-orcid":false,"given":"Katri","family":"Aro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Helsinki Head and Neck Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Helsinki Head and Neck Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Tarkkanen","sequence":"additional","affiliation":[{"name":"Department of Pathology HUSLAB, Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Atula","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Helsinki Head and Neck Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Department of Otorhinolaryngology Lapland Central Hospital, Wellbeing Services County of Lapland  Rovaniemi Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Head and Neck Tumours: WHO Classification of Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2024"},{"key":"e_1_2_11_3_1","volume-title":"The Milan System for Reporting Salivary Gland Cytopathology","author":"Faquin W. C.","year":"2018"},{"issue":"2","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/dc.24097","article-title":"Retrospective Assessment of the Effectiveness of the Milan System for Reporting Salivary Gland Cytology: A Systematic Review and Meta\u2010Analysis of Published Literature","volume":"47","author":"Farahani S. J.","year":"2019","journal-title":"Diagnostic Cytopathology"},{"issue":"1130","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20210972","article-title":"Ultrasound\u2010Guided Core Biopsy in the Diagnosis of Parotid Neoplasia: An Overview and Update With a Review of the Literature","volume":"95","author":"Hurry K. J.","year":"2022","journal-title":"British Journal of Radiology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"112532","DOI":"10.1016\/j.ejrad.2025.112532","article-title":"Fine\u2010Needle Aspiration or Core Needle Biopsy? A Meta\u2010Analysis of Diagnostic Accuracy and Procedural Outcomes in Salivary Gland Tumors","volume":"194","author":"Kassem K.","year":"2026","journal-title":"European Journal of Radiology"},{"issue":"1","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0194599815607841","article-title":"Sensitivity, Specificity, and Posttest Probability of Parotid Fine\u2010Needle Aspiration: A Systematic Review and Meta\u2010Analysis","volume":"154","author":"Liu C. C.","year":"2016","journal-title":"Otolaryngology and Head and Neck Surgery"},{"issue":"1","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1309\/AJCPOIE0CZNAT6SQ","article-title":"A Systematic Review and Meta\u2010Analysis of the Diagnostic Accuracy of Fine\u2010Needle Aspiration Cytology for Parotid Gland Lesions","volume":"136","author":"Schmidt R. L.","year":"2011","journal-title":"American Journal of Clinical Pathology"},{"issue":"6","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00405-020-05868-1","article-title":"The Role of Fine\u2010Needle Aspiration Biopsy (FNAB) in the Diagnostic Management of Parotid Gland Masses With Emphasis on Potential Pitfalls","volume":"277","author":"Dostalova L.","year":"2020","journal-title":"European Archives of Oto\u2010Rhino\u2010Laryngology"},{"issue":"10","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1002\/hed.26377","article-title":"Comparison of Core Needle Biopsy and Fine\u2010Needle Aspiration in Diagnosis of Malignant Salivary Gland Neoplasm: Systematic Review and Meta\u2010Analysis","volume":"42","author":"Cho J.","year":"2020","journal-title":"Head & Neck"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hed.23999","article-title":"Diagnostic Value of Core Needle Biopsy and Fine\u2010Needle Aspiration in Salivary Gland Lesions","volume":"38","author":"Novoa E.","year":"2016","journal-title":"Head & Neck"},{"issue":"11","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1007\/s00405-018-5131-0","article-title":"Preoperative Diagnostic of Parotid Gland Neoplasms: Fine\u2010Needle Aspiration Cytology or Core Needle Biopsy?","volume":"275","author":"Zb\u00e4ren P.","year":"2018","journal-title":"European Archives of Oto\u2010Rhino\u2010Laryngology"},{"issue":"1","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/lary.26764","article-title":"Ultrasound\u2010Guided Core Needle Biopsy in Salivary Glands: A Meta\u2010Analysis","volume":"128","author":"Kim H. J.","year":"2018","journal-title":"Laryngoscope"},{"issue":"3","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/lary.24339","article-title":"Ultrasound\u2010Guided Core Needle Biopsy of Salivary Gland Lesions: A Systematic Review and Meta\u2010Analysis","volume":"124","author":"Witt B. L.","year":"2014","journal-title":"Laryngoscope"},{"issue":"4","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1309\/AJCP5LTQ4RVOQAIT","article-title":"A Systematic Review and Meta\u2010Analysis of the Diagnostic Accuracy of Ultrasound\u2010Guided Core Needle Biopsy for Salivary Gland Lesions","volume":"136","author":"Schmidt R. 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A.","year":"2020","journal-title":"Head and Neck Pathology"},{"issue":"1","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"8832","DOI":"10.1038\/s41598-024-58892-0","article-title":"Clinical Decision Making When Cytology Indicates a Warthin Tumor","volume":"14","author":"Sirvi\u00f6 M.","year":"2024","journal-title":"Scientific Reports"},{"issue":"10","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hed.21821","article-title":"Role of Ultrasound\u2010Guided Core\u2010Needle Biopsy in the Assessment of Head and Neck Lesions: A Meta\u2010Analysis and Systematic Review of the Literature","volume":"34","author":"Novoa E.","year":"2012","journal-title":"Head & Neck"},{"issue":"11","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/hed.23193","article-title":"Comparison of Ultrasound\u2010Guided Core Biopsy Versus Fine\u2010Needle Aspiration Biopsy in the Evaluation of Salivary Gland Lesions","volume":"35","author":"Douville N. 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V.","year":"2016","journal-title":"British Journal of Oral & Maxillofacial Surgery"},{"issue":"11","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/hed.20891","article-title":"Comparison of Ultrasound\u2010Guided Core\u2010Needle Biopsy and Fine\u2010Needle Aspiration in the Assessment of Head and Neck Lesions","volume":"30","author":"Kraft M.","year":"2008","journal-title":"Head & Neck"},{"issue":"12","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/lary.24247","article-title":"Pleomorphic Adenoma of the Major Salivary Glands: Diagnostic Utility of FNAB and MRI","volume":"123","author":"Heaton C. M.","year":"2013","journal-title":"Laryngoscope"},{"issue":"10","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/hed.27099","article-title":"Cytologic Diagnosis of Parotid Gland Warthin Tumor: Systematic Review and Meta\u2010Analysis","volume":"44","author":"Fisher R.","year":"2022","journal-title":"Head & Neck"},{"issue":"11","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1002\/lary.26643","article-title":"Fine\u2010Needle Aspiration With Selective Use of Core Needle Biopsy of Major Salivary Gland Tumors","volume":"127","author":"Romano E. B.","year":"2017","journal-title":"Laryngoscope"},{"issue":"1","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","DOI":"10.1007\/s12105-024-01725-3","article-title":"An Institutional Experience of Core Needle Biopsy With Cooperative Implementation by Pathologists and Head and Neck Oncologists in Salivary Gland Carcinoma","volume":"18","author":"Kobayashi K.","year":"2024","journal-title":"Head and Neck Pathology"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:14:54Z","timestamp":1790910894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":25,"alternative-id":["10.1002\/lary.70954"],"URL":"https:\/\/doi.org\/10.1002\/lary.70954","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"lary.70954"}}