{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:53:16Z","timestamp":1791183196870,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To quantify associations between pretreatment patient\u2010reported health\u2010related quality of life (HRQoL) domains and overall survival in head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Embase, and Web of Science were searched from inception through July 27, 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Longitudinal studies evaluating validated patient\u2010reported HRQoL as a prognostic exposure were included. Adjusted hazard ratios (HRs) for overall survival were harmonized to a 10\u2010point worsening and pooled by domain using restricted maximum\u2010likelihood random\u2010effects models. Risk of bias, multiplicity, leave\u2010one\u2010out stability, cohort overlap, residual\u2010confounding sensitivity, and reporting completeness were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010two independent studies in 40 publications were included; 43 estimates contributed to meta\u2010analyses of 10 domains. Worse Global QoL (HR, 1.11; 95% CI, 1.08\u20131.14), physical functioning (1.16; 1.13\u20131.20), role functioning (1.09; 1.07\u20131.11), and social functioning (1.09; 1.06\u20131.12) were consistently associated with higher mortality and remained leave\u2010one\u2010out stable. Swallowing was associated with mortality (1.15; 1.02\u20131.29) but was sensitive to one study. Dyspnea was associated with higher mortality in the primary analysis (4 studies; HR, 1.16; 95% CI, 1.01\u20131.33), but the estimate was heterogeneous and unstable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pretreatment HRQoL provides multidimensional prognostic information, with Global QoL and physical, role, emotional, and social functioning showing the most consistent evidence. These domains may help prioritize pretreatment supportive\u2010care assessment, whereas sensitivity\u2010limited or very\u2010low\u2010certainty findings require further confirmation and should not be interpreted as actionable treatment targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      PROSPERO number: CRD420261461389.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70960","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:42:31Z","timestamp":1791182551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pretreatment Health\u2010Related Quality of Life and Survival in Head and Neck Cancer: A Meta\u2010Analysis"],"prefix":"10.1002","author":[{"given":"YuJie","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfei","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Second Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-4023","authenticated-orcid":false,"given":"Fangyan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.21733"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010020\u201002716\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29559"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201006441\u2010y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/978-94-007-0753-5_901","volume-title":"Encyclopedia of Quality of Life and Well\u2010Being Research","author":"Sprangers M. 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