{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:50:15Z","timestamp":1791337815122,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n Shared airway management in endolaryngeal surgery conflicts surgical access with adequate ventilation. This study compared the effects of High\u2010Frequency Jet Ventilation (HFJV) and Transnasal Humidified Rapid\u2010Insufflation Ventilatory Exchange (THRIVE) via High\u2010Flow Nasal Cannula (HFNC) on perioperative oxygenation, arterial CO\n 2<\/jats:sub>\n kinetics, and metabolic stability.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective randomized controlled study, 36 patients (ASA I\u2013II) undergoing elective endolaryngeal procedures were randomized into HFJV (\n n<\/jats:italic>\n \u2009=\u200918) or HFNC (\n n<\/jats:italic>\n \u2009=\u200918) groups. Both cohorts received standardized TIVA and neuromuscular blockade. Primary outcomes were longitudinal PaCO\n 2<\/jats:sub>\n changes at five intervals: baseline (T0), 10 (T1), 20 (T2), 30 (T3) minutes post\u2010induction, and at surgical conclusion (T4). Secondary outcomes included PaO\n 2<\/jats:sub>\n , pH, and lactate.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PaCO\n 2<\/jats:sub>\n levels were comparable at T0 and T1. At 20\u2009min (T2), PaCO\n 2<\/jats:sub>\n was significantly higher in the HFNC group (55.5 vs. 44.5\u2009mmHg;\n p<\/jats:italic>\n \u2009=\u20090.002). At surgical conclusion (T4), median PaCO\n 2<\/jats:sub>\n reached 66.5\u2009mmHg in the HFNC group versus 44.5\u2009mmHg in the HFJV group (\n p<\/jats:italic>\n \u2009<\u20090.001). Consequently, the HFNC group exhibited significantly lower pH (7.21 vs. 7.31;\n p<\/jats:italic>\n \u2009<\u20090.001) and elevated lactate (3.4 vs. 2.5\u2009mmol\/L;\n p<\/jats:italic>\n \u2009<\u20090.001) at T4. PaO\n 2<\/jats:sub>\n levels at T3 and T4 were significantly superior in the HFJV group (\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n While HFNC offers an ideal tubeless field for short interventions, its use is limited by time\u2010dependent hypercapnia and progressive respiratory acidosis. We propose a clinical \u201c20\u2010min threshold\u201d for HFNC; for longer endolaryngeal procedures, HFJV is preferred to maintain ventilatory and metabolic homeostasis.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n This clinical trial was registered at\n ClinicalTrials.gov<\/jats:ext-link>\n (registration number NCT05746949).\n <\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70970","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:55:37Z","timestamp":1791334537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Effects of High\u2010Flow Nasal Cannula Oxygen and Jet Ventilation Techniques"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-3068","authenticated-orcid":false,"given":"Seda","family":"\u00d6zda\u011fl\u0131","sequence":"first","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Anesthesiology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-6944","authenticated-orcid":false,"given":"Mert","family":"Canbaz","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Anesthesiology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-4890","authenticated-orcid":false,"given":"Emre","family":"\u00c7amc\u0131","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Anesthesiology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-7086","authenticated-orcid":false,"given":"Nil","family":"K\u0131r\u015fan","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Anesthesiology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4551-4999","authenticated-orcid":false,"given":"Basri","family":"Akdo\u011fan","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Anesthesiology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2279-3083","authenticated-orcid":false,"given":"Dilek","family":"Altun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Ac\u0131badem Mehmet Ali Ayd\u0131nlar University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-1621","authenticated-orcid":false,"given":"Mehmet","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Otolaryngology & Head and Neck Surgery Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-0865","authenticated-orcid":false,"given":"Demet","family":"Altun","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Anesthesiology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0022215100125733","article-title":"High\u2010Frequency Jet Ventilation\u2013A Review of Its Role in Laryngology","volume":"108","author":"Evans K. L.","year":"1994","journal-title":"Journal of Laryngology and Otology"},{"issue":"2","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5606\/kbbihtisas.2017.72368","article-title":"Endolarengeal cerrahide jet ventilasyon","volume":"27","author":"Altun Bing\u00f6l D.","year":"2017","journal-title":"Kulak Burun Bo\u011faz \u0130htisas Dergisi"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jvoice.2008.09.006","article-title":"Use of Lasers in Laryngeal Surgery","volume":"24","author":"Yan Y.","year":"2010","journal-title":"Journal of Voice"},{"issue":"2","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/0194599813486248","article-title":"Use of Apneic Oxygenation for the Performance of Pan\u2010 Endoscopy","volume":"149","author":"Rudlof B.","year":"2013","journal-title":"Otolaryngology and Head and Neck Surgery"},{"issue":"6","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1365-2044.2010.06331.x","article-title":"Litigation Related to Airway and Respiratory Complications of Anaesthesia: An Analysis of Claims Against the NHS in England 1995\u20102007","volume":"65","author":"Cook T. M.","year":"2010","journal-title":"Anaesthesia"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/bjaceaccp\/mkl061","article-title":"Jet Ventilation","volume":"7","author":"Evans E.","year":"2007","journal-title":"Continuing Education in Anaesthesia Critical Care & Pain"},{"issue":"4","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/arm91040022","article-title":"Application and Technical Principles of Catheter High\u2010Frequency Jet Ventilation","volume":"91","author":"Musil P.","year":"2023","journal-title":"Advances in Respiratory Medicine"},{"issue":"3","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.anclin.2010.07.001","article-title":"Jet Ventilation for Surgical Interventions in the Upper Airway","volume":"28","author":"Biro P.","year":"2010","journal-title":"Anesthesiology Clinics"},{"issue":"5","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.anl.2017.12.003","article-title":"High Frequency Jet Ventilation: Risk Factors for Complications","volume":"45","author":"Altun D.","year":"2018","journal-title":"Auris, Nasus, Larynx"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.18410\/jebmh\/2016\/751","article-title":"Supraglottic Jet Ventilation Versus Conventional Endotracheal Ventilation in Minor Laryngeal Surgeries","volume":"3","author":"Upendranath I.","year":"2016","journal-title":"Journal of Evidence Based Medicine and Healthcare"},{"issue":"1","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40560-015-0084-5","article-title":"High\u2010Flow Nasal Cannula Oxygen Therapy in Adults","volume":"3","author":"Nishimura M.","year":"2015","journal-title":"Journal of Intensive Care"},{"issue":"3","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/anae.12923","article-title":"Transnasal Humidified Rapid\u2010Insufflation Ventilatory Exchange (THRIVE): A Physiological Method of Increasing Apnoea Time in Patients With Difficult Airways","volume":"70","author":"Patel A.","year":"2015","journal-title":"Anaesthesia"},{"issue":"6","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/0310057X1103900620","article-title":"Evaluation of a Humidified Nasal High\u2010 Flow Oxygen System, Using Oxygraphy, Capnography and Measurement of Upper Airway Pressures","volume":"39","author":"Ritchie J. E.","year":"2011","journal-title":"Anaesthesia and Intensive Care"},{"issue":"12","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1177\/03000605221140685","article-title":"High\u2010Flow Nasal Oxygen for Suspension Laryngoscopy: A Multicenter Open\u2010Label Study","volume":"50","author":"Saad M.","year":"2022","journal-title":"Journal of International Medical Research"},{"issue":"3","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/bja\/aew468","article-title":"SponTaneous Respiration Using IntraVEnous Anaesthesia and Hi\u2010Flow Nasal Oxygen (STRIVE Hi) Maintains Oxygenation and Airway Patency During Management of the Obstructed Airway: An Observational Study","volume":"118","author":"Booth A. W. G.","year":"2017","journal-title":"British Journal of Anaesthesia"},{"issue":"11","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/anae.14036","article-title":"Apnoeic Oxygenation With High\u2010Flow Nasal Oxygen for Laryngeal Surgery: A Case Series","volume":"72","author":"Lyons C.","year":"2017","journal-title":"Anaesthesia"},{"issue":"4","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/bja\/aex036","article-title":"Apnoeic Oxygenation in Adults Under General Anaesthesia Using Transnasal Humidified Rapid\u2010 Insufflation Ventilatory Exchange (THRIVE) \u2013 A Physiological Study","volume":"118","author":"Gustafsson I. M.","year":"2017","journal-title":"British Journal of Anaesthesia"},{"issue":"18","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1113\/JP272404","article-title":"Cerebral Oxidative Metabolism Is Decreased With Extreme Apnoea in Humans; Impact of Hypercapnia","volume":"594","author":"Bain A. R.","year":"2016","journal-title":"Journal of Physiology"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fmed.2017.00247","article-title":"Monitoring of Tissue Oxygenation: An Everyday Clinical Challenge","volume":"4","author":"Molnar Z.","year":"2017","journal-title":"Frontiers in Medicine (Lausanne)"},{"issue":"1","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jvoice.2004.03.008","article-title":"Subglottic Jet Ventilation for Suspension Microlaryngoscopy","volume":"19","author":"Rubin J. S.","year":"2005","journal-title":"Journal of Voice"},{"issue":"3","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/bja\/59.3.295","article-title":"Cardiovascular and Catecholamine Responses to Laryngoscopy With and Without Tracheal Intubation","volume":"59","author":"Shribman A. J.","year":"1987","journal-title":"British Journal of Anaesthesia"},{"issue":"11","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1007\/s00464-011-1751-9","article-title":"The Effects of High\u2010Frequency Jet Ventilation (HFJV) on Pneumoperitoneum\u2010Induced Cardiovascular Changes During Laparoscopic Surgery","volume":"25","author":"Bickel A.","year":"2011","journal-title":"Surgical Endoscopy"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.rmed.2016.11.004","article-title":"High Flow Nasal Cannula Versus Conventional Oxygen Therapy and Non\u2010Invasive Ventilation in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review","volume":"121","author":"Lee C. C.","year":"2016","journal-title":"Respiratory Medicine"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70970","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:55:46Z","timestamp":1791334546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":23,"alternative-id":["10.1002\/lary.70970"],"URL":"https:\/\/doi.org\/10.1002\/lary.70970","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"lary.70970"}}