{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:38:37Z","timestamp":1792636717580,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early diagnosis and treatment of sinonasal malignant lymphoma are crucial because of its diverse clinical and imaging findings and poor prognosis associated with certain histological subtypes. However, the markers that predict the diagnosis and prognosis according to the histological subtypes are unclear. This study aimed to identify these markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 66 malignant lymphomas diagnosed using biopsy specimens obtained from the nasal cavity and sinus and treated at our institution. Age, sex, main symptom, primary site, disease stage, histopathological type, blood test parameters, follow\u2010up period, treatment details, and prognosis were analyzed. Overall survival was defined as the time from diagnosis to death from any cause. Progression\u2010free survival was defined as the time from diagnosis to disease progression, relapse, or death. Survival curves were estimated using the Kaplan\u2013Meier method and compared using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) was the most common histological subtype (45 patients), followed by extranodal natural killer (NK)\/T\u2010cell lymphoma (ENKTL; 15 patients). The 5\u2010year progression\u2010free survival rates were 50.0% for DLBCL and ENKTL for 28.1%. ENKTL was associated with a significantly poorer prognosis than DLBCL. Among patients with sinonasal DLBCL, CD5\u2010positivity tended to have a poorer prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sinonasal malignant lymphoma exhibits heterogeneous clinical behavior according to the histological subtype. CD5\u2010positive sinonasal DLBCL tended to result in worse outcomes. To our knowledge, this is the first study to investigate the prognostic significance of CD5 expression in sinonasal DLBCL. Further studies are needed to clarify its prognostic significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.71010","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:46:42Z","timestamp":1792633602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Clinical Study of 66 Cases of Sinonasal Malignant Lymphoma: Results of a Single\u2010Institution Study"],"prefix":"10.1002","author":[{"given":"Kohei","family":"Inomata","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kyorin University Suginami Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kyorin University Suginami Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Hematology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masachika","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-3553","authenticated-orcid":false,"given":"Hidenori","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kyorin University Suginami Hospital  Tokyo Japan"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880250015001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_45_17"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2015.08.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.815"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509049776"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009057638"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0600-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.00334.x"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"170","article-title":"Significance of Soluble Interleukin\u20102 Receptor Alpha Chain in the Management of Patients With Malignant Lymphoma: A Multi\u2010Center Study","volume":"43","author":"Ohno H.","year":"2002","journal-title":"Rinsh\u014d Ketsueki"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq627"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221110075"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-345256"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199203000-00037"},{"key":"e_1_2_10_17_1","volume-title":"World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Hematopoietic and Lymphoid Tissues","author":"Jaffe E. 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