{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:39:43Z","timestamp":1792553983106,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>Head and neck cancer\u2010related lymphedema (HNCRL) is a common, chronic consequence of head and neck cancer (HNC) treatment that contributes to progressive fibrosis, functional impairment, and reduced quality of life. Although early intervention is advocated, its association with longitudinal swallow outcomes remains poorly understood. This study evaluated whether early HNCRL treatment was associated with improved objective and patient\u2010reported swallowing outcomes following radiation treatment (RT) and\/or chemoradiation (CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records from 110 patients enrolled in a standardized HNC care pathway were retrospectively reviewed. Internal HNCRL was identified in all participants at 3\u2010months post\u2010RT\/CRT, when lymphedema treatment was recommended. Seventy\u2010two patients completed treatment with an advanced pneumatic compression device (APCD) or manual lymphatic drainage (MLD), while 38 did not. Swallowing physiology, patient\u2010reported outcomes, and maximum interincisal opening (MIO) were evaluated at baseline, 3\u2010months, and 15\u2010months post\u2010RT\/CRT. Longitudinal within\u2010 and between\u2010group comparisons were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treated patients demonstrated significantly more favorable longitudinal DIGEST outcomes for overall severity, swallowing safety, and swallowing efficiency (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), greater improvement in EAT\u201010 (\u22123.63 vs. +1.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and RSI (\u22125.21 vs. +2.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and no significant difference in MIO change (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.259) or cancer recurrence. Associations for DIGEST, EAT\u201010, and RSI remained significant after multivariable adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early HNCRL treatment was associated with greater improvements in swallowing physiology and patient\u2010reported swallowing outcomes. These findings support routine HNCRL surveillance and timely intervention within multidisciplinary HNC care pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.71011","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:57:21Z","timestamp":1792551441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Swallowing Outcomes Following Early Treatment of Head and Neck Cancer\u2010Related Lymphedema"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-3430","authenticated-orcid":false,"given":"Jessica W.","family":"Gregor","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Charney","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Zacharias","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Skrove","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-9687","authenticated-orcid":false,"given":"David G.","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40141\u2010026\u201000533\u2010w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2021.26.Sup4.S24"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11764\u2010024\u201001683\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010022\u201010526\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26394"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201007698\u20103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010022\u201001227\u2010x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26484"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2016.0001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2019.0034"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12134"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.05.025"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.04.013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23084"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2016.0018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12894"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2016.0174"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.10.027"},{"key":"e_1_2_10_20_1","first-page":"1","article-title":"Late Effect Laryngeal Oedema\/Lymphoedema","volume":"26","author":"Murphy B.","year":"2014","journal-title":"Wounds International"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgz005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2020.03.20"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010016\u20109710\u20101"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2011.08.535"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/pmrj.13340","article-title":"Prevalence of Function\u2010Limiting Late Effects in Survivors of Head and Neck Cancer","volume":"17","author":"Won Y. 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