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MASLD can advance to metabolic dysfunction\u2010associated steatohepatitis (MASH). These conditions often lead to hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC) if not timely diagnosed and managed; thus, molecular phenotyping of MASLD and MASH conditions is highly desirable. The analyses were performed to identify distinct, differentially expressed genes, particularly noncoding ones, in MASLD and MASH patient samples, thereby expanding diagnostic and therapeutic options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted the data from a recent transcriptomic study by Govaere et\u00a0al. on MASLD and MASH patient samples. We focused on transcripts with limited coding potential to broaden the scope of biomarker or therapeutic target identification, given their very specific expression patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This analysis identified long noncoding RNAs (lncRNAs) that are differentially expressed among MASLD and MASH conditions. Among the up\u2010regulated lncRNAs, 49 were specific to MASLD, such as\n                      <jats:italic>MYCNOS<\/jats:italic>\n                      . In contrast, 88 were unique to MASH, such as\n                      <jats:italic>ELFN2\u2010208<\/jats:italic>\n                      ,\n                      <jats:italic>LINC01507<\/jats:italic>\n                      and\n                      <jats:italic>LINC01435<\/jats:italic>\n                      . Similarly, among the down\u2010regulated noncoding transcripts, 93 were unique to MASLD, including\n                      <jats:italic>AADACL2\u2010AS1<\/jats:italic>\n                      and\n                      <jats:italic>ST8SIA6\u2010AS1<\/jats:italic>\n                      , whereas 132 were unique to MASH, such as\n                      <jats:italic>SYBU\u2010AS1<\/jats:italic>\n                      ,\n                      <jats:italic>LGALS17A\u2010207, ZNF474\u2010AS1<\/jats:italic>\n                      and\n                      <jats:italic>LINC01116<\/jats:italic>\n                      . Additionally, we employed the Genomic Regions Enrichment of Annotations Tool (GREAT) to assess their functional relevance in MASLD or MASH and to link them to biologically meaningful terms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study broadens the scope of noncoding RNA\u2010based MASLD\/MASH biomarker and therapeutic target identification, which ultimately aids early diagnosis of these prominent liver diseases and helps prevent advanced liver diseases such as HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lci2.70053","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:42:18Z","timestamp":1784270538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noncoding\n                    <scp>RNA<\/scp>\n                    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