{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T14:05:42Z","timestamp":1780149942055,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this meta\u2010analysis was to compare the efficiency of high\u2010resolution computed tomography (HRCT) and diffusion\u2010weighted magnetic resonance imaging (DWI) in guiding the diagnosis of middle ear cholesteatoma in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Cochrane Library, Medline, Embase, PubMed, and Web of Science were searched for studies that evaluated the sensitivity and specificity of HRCT or DWI in detecting middle ear cholesteatoma. A random\u2010effects model was used to calculate and summarize the pooled estimates of sensitivity, specificity, and diagnostic odds ratios. Postoperative pathological results were considered as the diagnostic gold standard for middle ear cholesteatoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen published articles (860 patients) met the inclusion criteria. The sensitivity and specificity of DWI when diagnosing cholesteatoma (regardless of type) were 0.88 (95% confidence interval [CI], 0.80\u20130.93) and 0.93 (95% CI, 0.86\u20130.97), respectively, while those of HRCT were 0.68 (95% CI, 0.57\u20130.77) and 0.78 (95% CI, 0.60\u20130.90), respectively. Notably, the sensitivity and specificity levels of DWI were similar to those of HRCT (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.1178 for sensitivity, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.2144 for specificity; pair\u2010sampled <jats:italic>t<\/jats:italic> tests). The sensitivity and specificity of DWI or HRCT for the diagnosis of primary cholesteatoma were 0.78 (95% CI, 0.65\u20130.88) and 0.84 (95% CI, 0.69\u20130.93), respectively, while that for recurrent cholesteatoma were 0.93 (95% CI, 0.61\u20130.99) and 0.94 (95% CI, 0.82\u20130.98), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DWI and HRCT have similar levels of high sensitivity and specificity in detecting various cholesteatomas. Also, the diagnostic efficiency of HRCT or DWI for recurrent cholesteatoma is identical to that of primary cholesteatoma. Therefore, HRCT may be used in clinical settings to reduce the use of DWI and save clinical resources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay summary<\/jats:title><jats:p>Data on the use of diffusion\u2010weighted magnetic resonance imaging and high\u2010resolution computed tomography in the diagnosis of cholesteatoma were obtained through a literature search. They were analyzed to guide the clinical diagnosis and treatment of cholesteatoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>NA<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1032","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T11:22:08Z","timestamp":1680693728000},"page":"627-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The diagnostic utility of diffusion\u2010weighted magnetic resonance imaging and high\u2010resolution computed tomography for cholesteatoma: A meta\u2010analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-4460","authenticated-orcid":false,"given":"Mengzhao","family":"Xun","sequence":"first","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Hearing Medicine 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