{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:10:30Z","timestamp":1793873430298,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Safety and efficacy of the NEUROMARK\u00ae system for treating chronic rhinitis.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective, single\u2010arm, multicenter study was performed on adults with chronic rhinitis who underwent radiofrequency ablation to the posterior nasal nerves. Primary endpoints were device\u2010related serious adverse events (SAEs) at 1\u2009month and change from baseline in visual analog scale nasal symptom scale (VAS NSS) for rhinorrhea and nasal congestion at 3\u00a0months. Total nasal symptom score (rTNSS) and mini Rhinoconjunctivitis Quality of Life Questionnaire (mini RQLQ) score were also evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010six participants were enrolled and completed follow\u2010up at 1 and 3\u2009months. Mean VAS NSS scores for rhinorrhea and nasal congestion demonstrated significant improvement at 3\u2009months (both p<\/jats:italic>\u2009<\u2009.0001). The mean percent changes from baseline in VAS rhinorrhea and nasal congestion were 53% and 55%, respectively. Total scores and all individual rTNSS items significantly improved (all p<\/jats:italic>\u2009<\u2009.001) over the measured interval. Percent responder rate (\u226530% reduction from baseline in total rTNSS) at 3\u00a0months was 78%. The total mean mini RQLQ scores, as well as all subdomains, improved significantly (all p<\/jats:italic>\u2009<\u2009.0001). At 3\u00a0months, 89% of participants reported a minimal clinically important difference of \u22650.4 point improvement in the mini RQLQ score. No SAEs occurred during the study.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The NEUROMARK System is a novel radiofrequency ablation device that provides safe and effective treatment to the posterior nasal nerves for patients with chronic rhinitis. Study participants experienced statistically significant and clinically meaningful improvement in symptoms and quality of life assessments at 3\u00a0months post\u2010procedure.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>The study is registered at www.clinicaltrials.gov<\/jats:ext-link> with the unique identifier of NCT05324397.<\/jats:p><\/jats:sec>Level of Evidence<\/jats:title>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1040","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T15:35:00Z","timestamp":1678980900000},"page":"367-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical evaluation of a novel multipoint radiofrequency ablation device to treat chronic rhinitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Douglas D.","family":"Reh","sequence":"first","affiliation":[{"name":"Centers for Advanced ENT Care Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Lay","sequence":"additional","affiliation":[{"name":"Alabama Nasal and Sinus Center Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Davis","sequence":"additional","affiliation":[{"name":"ENT and Allergy Associates Seattle and Puyallup Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Dubin","sequence":"additional","affiliation":[{"name":"Centers for Advanced ENT Care Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Specialty Physician Associates Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-764X","authenticated-orcid":false,"given":"Ellen 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