{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:41:21Z","timestamp":1768254081512,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,8]]},"abstract":"Abstract<\/jats:title>We utilized a case control study to determine if novel oral anticoagulants were associated with a higher risk of inpatient epistaxis admission. Adult patients admitted with a principal diagnosis of epistaxis in 2019\u20132021 were identified as well as a control group of patients matched 1:1 for age, sex, race, and medical comorbidities. For both cohorts, the presence or absence of an oral anticoagulant, classified as vitamin K inhibitors, direct oral anticoagulants (DOAC) or platelet inhibitors, was identified. 158 adult unique inpatient admissions with a principal diagnosis of epistaxis were identified. Vitamin K inhibition was present in 5.7% of cases versus 0.6% of controls (p<\/jats:italic>\u00a0=\u00a00.02; OR 9.48, range 1.19\u201075.77), DOACs in 4.4% of cases versus 5.1% of controls (p<\/jats:italic>\u00a0=\u00a01.0) and platelet inhibitors in 2.5% of cases versus 3.8% of controls (p<\/jats:italic>\u00a0=\u00a00.75). We concluded vitamin K inhibitors, compared to DOACs and platelet inhibitors, may be associated with higher likelihood of epistaxis admission.<\/jats:p>","DOI":"10.1002\/lio2.1111","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T14:23:09Z","timestamp":1689344589000},"page":"824-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of inpatient epistaxis admission related to oral anticoagulation medication use"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-7670","authenticated-orcid":false,"given":"Margaret B.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head & Neck Surgery Massachusetts Eye & Ear Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-6472","authenticated-orcid":false,"given":"Alan D.","family":"Workman","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head & Neck Surgery Massachusetts Eye & Ear Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lu","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-5824","authenticated-orcid":false,"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head & Neck Surgery Massachusetts Eye & Ear Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.11.031"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886313666180213090943"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491513000614"},{"key":"e_1_2_5_5_1","unstructured":"IBM Truven Health Analytics.12 months ending December 31 2018 for commercial Medicare and Medicaid Patients;2019."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2021.1693"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017559"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.061"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.541"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5058"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110001921"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560\u2010016\u20100144\u20105"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.008904"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.1111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T16:18:23Z","timestamp":1695140303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.1111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/lio2.1111"],"URL":"https:\/\/doi.org\/10.1002\/lio2.1111","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]},"assertion":[{"value":"2023-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}