{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:20:27Z","timestamp":1760080827253,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if simultaneous administration of acoustic vibration and oscillating expiratory pressure affects the severity of facial pain among patients with complaint of \u201csinus headache\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective single\u2010arm observational study performed at a tertiary care medical center. Subjects with complaint of sinus headache without evidence of chronic rhinosinusitis on exam or computed tomography participated in a clinical study applying simultaneous acoustic vibrations and positive expiratory pressure to the nasal cavity twice daily over 4\u2009weeks. Efficacy was assessed using three validated pain metrics\u2014pain visual analog scale (VAS), brief pain inventory\u2010short form (BPI\u2010SF), and McGill pain questionnaire\u2010short form (MPQ\u2010SF). Device safety and patient satisfaction were also assessed using questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine patients (mean age 49\u2009years, 55% female) completed the study without any major adverse events. At the 4\u2009week follow\u2010up, facial pain VAS improved from mean\u2009\u00b1\u2009SD of 59.6\u2009\u00b1\u200915.7 to 34.6\u2009\u00b1\u200921.7 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), BPI mean pain (mean\u2009\u00b1\u2009standard deviation) improved from 4.4\u2009\u00b1\u20092.0 to 2.9\u2009\u00b1\u20091.9 (<jats:italic>p<\/jats:italic>\u2009=\u2009.007), and MPQ\u2010SF total improved from 12.2\u2009\u00b1\u20096.5 to 6.5\u2009\u00b1\u20095.2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) with approximately 70% of patients achieving a minimal clinically important difference (MCID) across all metrics. Additionally, pain VAS was assessed 5\u2009min after a single use at baseline with significant improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Eighty\u2010six percent of subjects would both use device again and recommend it to others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simultaneous administration of acoustic vibration and oscillating expiratory pressure appears to be a safe treatment for sinus headaches in patients without objective evidence of chronic sinusitis. Results from this initial study are promising with regard to efficacy in treatment of sinus headaches but will require further study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>2c.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1124","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T11:38:34Z","timestamp":1690544314000},"page":"839-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of sinus headache using a device that combines acoustic vibration with oscillating expiratory pressure"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4345","authenticated-orcid":false,"given":"Amar","family":"Miglani","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Division of Rhinology and Skull Base Surgery, Department of Otolaryngology\u2010Head &amp; Neck Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Germroth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina A.","family":"LaPointe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-4571","authenticated-orcid":false,"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted A.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2018.32.4501"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24926"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.024"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21095"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22537"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20543"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(87)91074\u20108"},{"key":"e_1_2_7_9_1","article-title":"The brief pain inventory user guide","author":"Cleeland C","year":"2009","journal-title":"Br Pain Invent"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2020.102108"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30499\u2010X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202\u2010138BC"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010020\u201001134\u20101"},{"issue":"3","key":"e_1_2_7_14_1","first-page":"271","article-title":"Treatment of acute migraine headache","volume":"83","author":"Gilmore B","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315579627"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318182f81d"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818772818"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2012.02265.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2711"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010019\u20100743\u20107"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.039"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110312.36809.7F"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.1124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T16:20:04Z","timestamp":1695140404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.1124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/lio2.1124"],"URL":"https:\/\/doi.org\/10.1002\/lio2.1124","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"type":"print","value":"2378-8038"},{"type":"electronic","value":"2378-8038"}],"subject":[],"published":{"date-parts":[[2023,7,28]]},"assertion":[{"value":"2023-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}