{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:45:42Z","timestamp":1783183542324,"version":"3.54.6"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Head and neck cancer (HNC) survivorship issues are areas of increasing research interest. Laryngeal dysfunction in HNC patients is particularly important given the importance of the larynx in voice, swallowing, and airway protection. The objective of our study is to characterize late laryngeal dysfunction in a cohort of long\u2010term HNC survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HNC survivors who were at least 2\u2009years post\u2010treatment were recruited prospectively for standard collection of videolaryngoscopy findings, videofluoroscopic swallowing studies, and assessment of clinical outcomes. Descriptive statistics were performed and clinical presentation and outcomes were compared between survivors &gt;10\u2009years and &lt;10\u2009years post\u2010treatment. Additional factor analysis to correlate clinical outcomes with clinical variables was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty participants were analyzed with a mean age of 66\u2009years. The majority were male (80%) patients treated for oropharyngeal squamous cell carcinoma (67%). Within the cohort, 43% underwent primary chemoradiation therapy and had 13% radiation alone. Common presenting symptoms included swallowing dysfunction (83%), voice change (67%), and chronic cough (17%). Laryngeal findings on video laryngoscopy include vocal fold motion abnormalities (VFMA) in over half of participants (61%) and mucosal changes in 20%. A weak correlation was found between time since treatment and laryngeal dysfunction (<jats:italic>r<\/jats:italic>\u2009=\u2009.182, <jats:italic>p<\/jats:italic>\u2009=\u2009.34), and no correlation was found between age, sex, time since treatment, or primary site and the presence or absence of VFMA, G\u2010tube status, or tracheostomy\u2010tube status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Late laryngeal dysfunction in HNC survivors contributes to significant morbidity, is difficult to treat, and remains static decades after treatment for their original cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>The voice\u2010box, or the larynx, plays an important role in voice, swallowing and airway protection. It is particularly vulnerable to radiation\u2010related damage and changes. This study demonstrates the sequelae of long\u2010term damage of the larynx in head and cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>IV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1128","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T13:13:34Z","timestamp":1690809214000},"page":"1272-1278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Late laryngeal dysfunction in head and neck cancer survivors"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9638-398X","authenticated-orcid":false,"given":"Sarah","family":"Almas","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery, Department of Surgery, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta 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