{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:45:40Z","timestamp":1781520340060,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:00:00Z","timestamp":1692403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Use of computational fluid dynamic (CFD) simulations to measure the changes in upper airway geometry and aerodynamics during (a) an episode of Exercise\u2010Induced Laryngeal Obstruction (EILO) and (b) speech therapy exercises commonly employed for patients with EILO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Magnetic resonance imaging stills of the upper airway including the nasal and oral cavities from an adult female were used to re\u2010construct three\u2010dimensional geometries of the upper airway. The CFD simulations were used to compute the maximum volume flow rate (l\/s), pressure (Pa), airflow velocity (m\/s) and area of cross\u2010section opening in eight planes along the vocal tract, separately for inhalation and exhalation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Numerical predictions from three\u2010dimensional geometrical modeling of the upper airway suggest that the technique of nose breathing for inhalation and pursed lip breathing for exhalation show most promising pressure conditions and cross\u2010sectional diameters for rescue breathing exercises. Also, if EILO is due to the constriction at the vocal fold level, then a quick sniff may also be a proper rescue inhalation exercise. EILO affects both the inspiratory and the expiratory phases of breathing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A prior knowledge of the supraglottal aerodynamics and the corresponding upper airway geometry from CFD analysis has the potential to assist the clinician in choosing the most effective rescue breathing technique for optimal functional outcome of speech therapy intervention in patients with EILO and in understanding the pathophysiology of EILO on a case\u2010by\u2010case basis with future studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1140","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:57:34Z","timestamp":1692694654000},"page":"1294-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Computational fluid dynamics of upper airway aerodynamics for exercise\u2010induced laryngeal obstruction: A feasibility study"],"prefix":"10.1002","volume":"8","author":[{"given":"Michael","family":"D\u00f6llinger","sequence":"first","affiliation":[{"name":"Division of Phoniatrics and Pediatric Audiology at the Department of Otorhinolaryngology Head &amp; 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