{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:39:10Z","timestamp":1792640350677,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Platelet\u2010rich plasma (PRP) is rich in growth factors and is easily obtained from blood samples. Long\u2010term data after PRP injection into the larynx should be improved. This study reports the short\u2010term (3\u2009months) and long\u2010term (12\u2009months) voice results after PRP injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixty\u2010three patients with scars (<jats:italic>n<\/jats:italic>\u2009=\u200934), sulcus vocalis (<jats:italic>n<\/jats:italic>\u2009=\u200917), recalcitrant nodules (<jats:italic>n<\/jats:italic>\u2009=\u20095), atrophy (<jats:italic>n<\/jats:italic>\u2009=\u20094), or a combination of these (<jats:italic>n<\/jats:italic>\u2009=\u20093) were included (158 injections; median follow\u2010up\u2009=\u200912.3\u2009months). Stroboscopy, voice handicap index (VHI\u201010), and cepstral spectral index of dysphonia (CSID) before and after treatment (3\u2009months) and at 12\u2009months were tabulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VHI\u201010 changed from 19.5 to 14 at 3 months and 21 to 15 in the long term. The CSID scores improved from 31 to 21 in the short term and 31 to 26 in the long term (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, paired <jats:italic>t<\/jats:italic>\u2010test). Patients reported improved vocal effort and stamina with slight VHI or CSID score changes. Stroboscopy revealed improved closure and mucosal waves. Patients with severe dysphonia were less likely to improve compared to those with mild to moderate dysphonia. Some patients showed short\u2010term improvements and then deteriorated back to baseline CSID over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, paired <jats:italic>t<\/jats:italic>\u2010test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both short\u2010 and long\u2010term improvements in voice following PRP injection have been reported. Patients with mild\u2010to\u2010moderate dysphonia had better outcomes. PRP injection is an alternative treatment for patients with mild\u2010to\u2010moderate dysphonia due to vocal fold scarring, sulcus, and atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>II Prospective case series treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1143","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:47:55Z","timestamp":1693918075000},"page":"1304-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Platelet\u2010rich plasma in treatment of scar, atrophy, and sulcus: Short\u2010 and long\u2010term results"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-5178","authenticated-orcid":false,"given":"Peak","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21780"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500303"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24536"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700606"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283402a3b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32833fe112"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27731"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.10.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100801"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22389"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01632-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22143"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26138"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2016.11.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.04.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0842-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25578"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29200"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184581"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40778-016-0034-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.12.040"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2021.02.022"},{"key":"e_1_2_8_25_1","article-title":"Safety of platelet\u2010rich plasma subepithelial infusion for vocal fold scar, sulcus, and atrophy","volume":"133","author":"Woerd B","year":"2023","journal-title":"Laryngoscope"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121004564"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.07.012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030725"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-40117-6_19"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.150734"},{"key":"e_1_2_8_31_1","first-page":"245","article-title":"Ceptral voice analysis: link with perception and stroboscopy","volume":"119","author":"Dejonckere PH","year":"1998","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699200903242988"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.04.002"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212101205"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32833febf2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26855"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2014.7.1.47"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200708"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400409"},{"issue":"670","key":"e_1_2_8_40_1","first-page":"e677","article-title":"Regenerative medicine of the larynx. Where are we today? A review","volume":"26","author":"Gugatschka M","year":"2012","journal-title":"J Voice"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.1143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T12:36:46Z","timestamp":1698323806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.1143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/lio2.1143"],"URL":"https:\/\/doi.org\/10.1002\/lio2.1143","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,5]]},"assertion":[{"value":"2023-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}