{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:23:25Z","timestamp":1790709805175,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"a Grant-in-Aid for Research on Intractable Vestibular Disorder from Japan AMED"},{"name":"Japan Organization of Occupational Health and Safety"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Objective\/Hypothesis<\/jats:title>Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.<\/jats:p><\/jats:sec>Study Design<\/jats:title>Prospective, single\u2010arm repeated measures<\/jats:p><\/jats:sec>Methods<\/jats:title>Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium\u2010enhanced inner ear magnetic resonance (MR) imaging and neuro\u2010otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.<\/jats:p><\/jats:sec>Results<\/jats:title>The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13\u201391% of the pre\u2010treatment level. The volume ratio of post\u2010treatment EH\u2010to\u2010pre\u2010treatment EH ranged from 1.01\u20133.22. The total volume of pre\u2010treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.<\/jats:p><\/jats:sec>Level of Evidence<\/jats:title>2b.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.115","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T05:02:41Z","timestamp":1509426161000},"page":"344-350","source":"Crossref","is-referenced-by-count":27,"title":["Longitudinal up\u2010regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-8166","authenticated-orcid":false,"given":"Munehisa","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan"},{"name":"Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Nara Medical University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Oya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Akahani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Inohara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flio2.115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T18:35:59Z","timestamp":1696012559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/lio2.115"],"URL":"https:\/\/doi.org\/10.1002\/lio2.115","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}