{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:46:56Z","timestamp":1790916416959,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Anterior active rhinomanometry (AAR) is widely used in Swedish routine clinical practice to decide if septoplasty is necessary. The scientific basis for the method needs to be strengthened. Therefore, the aims were to evaluate nasal airway resistance (NAR), paradoxical reactions to pharmacological decongestion, and test\u2013retest characteristics of the Rhino\u2010Comp\u00ae AAR in healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective longitudinal design was used. AAR was performed before and after decongestion at baseline and after \u22656\u2009months on 60 healthy volunteers. The relationships between NAR, height, weight, BMI, sex, and allergic rhinitis were evaluated by regression analyses. Descriptive statistics were used to evaluate paradoxical reactions. Test\u2013retest and repeatability characteristics were evaluated with intra\u2010class coefficients (ICC), Cronbach's \u03b1, and standard error of measurement<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were found between genders or nasal cavity sides. NAR was statistically significantly related to height. Short\u2010 and long\u2010term test\u2013retest characteristics were good with ICC and Cronbach's <jats:italic>\u03b1<\/jats:italic>\u2009&gt;\u2009.75. The minimal significant difference in NAR Log10V2 values between the two measurements was 0.11 and 0.09 (long\u2010 and short\u2010term). Paradoxical reactions to pharmacological decongestion were rare, mostly weak, and not evidently reproducible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we report reference data for healthy subjects, test\u2013retest capabilities, and the minimal relevant difference between two measurements for the Rhino\u2010Comp\u00ae AAR, information that is vital and necessary for the appropriate use of AAR in clinical practice. An effective method for pharmacological decongestion is described and recommended for future studies and clinical practice. Paradoxical reactions to pharmacological decongestants exist but maybe without clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1157","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:29:15Z","timestamp":1695990555000},"page":"1136-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Active anterior rhinomanometry: A study on nasal airway resistance, paradoxical reactions to decongestion, and repeatability in healthy subjects"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-0182","authenticated-orcid":false,"given":"Ola","family":"Sunnergren","sequence":"first","affiliation":[{"name":"Ear, Nose and Throat Clinic Region J\u00f6nk\u00f6ping County  J\u00f6nk\u00f6ping Sweden"},{"name":"Centre for Oral Health, Department of Odontology and Oral Health, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Ahonen","sequence":"additional","affiliation":[{"name":"Centre for Oral Health, Department of Odontology and Oral Health, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Ear Nose and Throat Diseases, Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Brostr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"},{"name":"Department of Clinical Neurophysiology University Hospital Link\u00f6ping  Link\u00f6ping Sweden"},{"name":"Department of Health and Caring Sciences Western Norway University of Applied Sciences  Bergen Vestlandet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"issue":"28","key":"e_1_2_10_2_1","first-page":"1","article-title":"European position paper on diagnostic tools in rhinology","volume":"57","author":"Rimmer J","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_10_3_1","unstructured":"The Swedish Septoplasty Register.Public statistics page.https:\/\/sep.registercentrum.seIn Swedish. Accessed May 19 2023"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"6","article-title":"Rinomanometri\u2014Hur g\u00f6r vi runt om i landet? Hur kan vi bli b\u00e4ttre?","volume":"30","author":"Sunnergren O","year":"2022","journal-title":"Svensk \u00d6NH\u2010Tidskrift"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209128900"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"169","article-title":"Standardisation committee on objective assessment of the nasal airway, IRS, and ERS. 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