{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:20:59Z","timestamp":1787862059640,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness of ultrasound\u2010guided injection of botulinum toxin type A (BTX\u2010A) in treating sialorrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 32 sialorrhea subjects and they received an ultrasound\u2010guided injection of BTX\u2010A. The extent of salivation was evaluated according to the Visual Analog Scale (VAS), Drooling Severity and Frequency Scale (DSFS), and Saliva Flow Rate (SFR). Laryngeal secretions were evaluated based on Fiberoptic Endoscopic Evaluation of Swallowing (FEES) rated according to the Murray Secretion Scale (MSS). We assessed the extent of salivation and laryngeal secretions before injection and at 1, 2, and 4\u2009weeks after injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The scores for the VAS, DSFS\u2010S, DSFS\u2010F, and DSFS\u2010T decreased significantly at 1, 2, and 4\u2009weeks after injection compared with before injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Based on VAS, the efficacy was substantially higher at 2 and 4\u2009weeks after injection than at 1\u2009week after injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). According to DSFS\u2010S and DSFS\u2010T, the efficacy was significantly higher at 4\u2009weeks than at 1\u2009week after injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The SFR and MSS scores at 1 and 2\u2009weeks after injection were superior to those before injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Meanwhile, the SFR score 2\u2009weeks after injection was superior to that 1\u2009week after injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ultrasound\u2010guided injection of BTX\u2010A can effectively reduce saliva secretion in patients with neurogenic dysphagia. Furthermore, it has the advantages of early onset time and lasting curative effects, which indicates that clinical promotion and application of this technique are justified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1164","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:30:42Z","timestamp":1697074242000},"page":"1607-1615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effectiveness of ultrasound\u2010guided injection of BTX\u2010A in the management of sialorrhea in neurogenic dysphagia patients"],"prefix":"10.1002","volume":"8","author":[{"given":"Zitong","family":"He","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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