{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:04:42Z","timestamp":1770329082687,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Age\u2010related hearing loss (presbycusis) is a prevalent condition traditionally attributed to inner ear dysfunction. Little is known about age\u2010related changes in the ossicular joints or their contribution to presbycusis. Herein, we performed an otopathologic evaluation of the ossicular joints in cases of presbycusis without a clear sensorineural explanation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histopathologic analysis of the incudomallear (IM) and incudostapedial (IS) joints was performed in specimens from the National Temporal Bone Registry with audiometrically confirmed presbycusis but without histologically observed sensorineural, strial, or mixed features; deemed cases of \u201cindeterminate\u201d presbycusis. Specimens identified as \u201cindeterminate\u201d presbycusis (IP, <jats:italic>n<\/jats:italic>\u2009=\u200918) were compared to specimens with histologically confirmed sensorineural presbycusis (<jats:italic>n<\/jats:italic>\u2009=\u200916) and strial presbycusis (<jats:italic>n<\/jats:italic>\u2009=\u200911). Presbycutic specimens were also compared to age\u2010matched controls (<jats:italic>n<\/jats:italic>\u2009=\u20099) and young controls (<jats:italic>n<\/jats:italic>\u2009=\u200914).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The synovial space at the center of the IM joint was wider in the IP group (194\u2009\u00b1\u200936.8\u2009\u03bcm) compared to age\u2010matched controls (138\u2009\u00b1\u200936.5\u2009\u03bcm), young controls (149\u2009\u00b1\u200932.2\u2009\u03bcm), and ears with sensorineural presbycusis (148\u2009\u00b1\u200952.7\u2009\u03bcm) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The synovial space within the IS joint was wider in the IP group (105\u2009\u00b1\u200933.0\u2009\u03bcm) when compared to age\u2010matched controls (57.9\u2009\u00b1\u200913.1\u2009\u03bcm) and ears with sensorineural presbycusis (62.3\u2009\u00b1\u200931.2\u2009\u03bcm) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IP ears have wider IM and IS joints when compared to ears with sensorineural presbycusis and age\u2010matched controls. Findings point to a potential middle ear source of high frequency conductive hearing loss in a subset of presbycutic ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1197","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T07:55:39Z","timestamp":1706774139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ossicular joint histopathology in cases of age\u2010related hearing loss"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-9417","authenticated-orcid":false,"given":"Prithwijit","family":"Roychowdhury","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Castillo\u2010Bustamante","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc D.","family":"Polanik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Massachusetts Chan Medical School  Worcester Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Pennsylvania State University, College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott D.","family":"Kozin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-6264","authenticated-orcid":false,"given":"Aaron K.","family":"Remenschneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear  Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Massachusetts Chan Medical School  Worcester Massachusetts 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