{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:19:30Z","timestamp":1759133970261,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the sensitivity of laryngeal findings in predicting high\u2010grade dysplasia\/carcinoma in situ (CIS) and squamous cell carcinoma (SCC) in patients with vocal fold leukoplakia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of the medical records and video recordings of the laryngeal examination of patients with vocal fold leukoplakia who underwent un\u2010sedated office\u2010based laryngeal biopsy in a tertiary referral center between January 2022 and August 2023 was conducted. Laryngeal findings included the size, surface, projection, and edges of the lesion. Vocal fold leukoplakia was classified according to the WHO as benign, low\u2010grade dysplasia, high\u2010grade dysplasia\/CIS, and squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients with 100 vocal fold leukoplakia were included. Size was found to have the highest sensitivity with an AUC of 0.730 (95% CI [0.618\u20130.842], <jats:italic>p<\/jats:italic>\u2009=\u20090.002) followed by surface and projection with AUCs of 0.672 (95% CI [0.548\u20130.795], <jats:italic>p<\/jats:italic>\u2009=\u20090.019) and 0.675 (95% CI [0.546\u20130.804], <jats:italic>p<\/jats:italic>\u2009=\u20090.017), respectively. Furthermore, the odds of diagnosing high\u2010risk lesions (high\u2010grade dysplasia\/CIS and SCC) were the greatest when the lesion was large and rough (OR\u2009=\u200910.28; 95% CI [3.08\u201334.36]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The morphological features of vocal fold leukoplakia may assist the physician in predicting the risk of malignancy. Large and rough lesions were more likely to harbor high\u2010grade dysplasia\/CIS and SCC compared to small and smooth lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1209","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T11:29:29Z","timestamp":1704367769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The sensitivity of laryngeal findings in predicting high\u2010grade dysplasia in patients with vocal fold leukoplakia undergoing office\u2010based biopsies: A retrospective analysis of 100 cases"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-3486","authenticated-orcid":false,"given":"Jad","family":"Hosri","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Aoun","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"Yammine","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Ghadieh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-3568","authenticated-orcid":false,"given":"Abdul\u2010Latif","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000406"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.02.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21432"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24884"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1347826"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180590"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194697"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24368"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.04.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2019.04.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2021.1951444"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.11.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419888947"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537\u2010200108000\u201000001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010021\u201001405\u20106"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23781"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25930"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.138"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.1209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T12:13:19Z","timestamp":1708690399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/lio2.1209"],"URL":"https:\/\/doi.org\/10.1002\/lio2.1209","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"type":"print","value":"2378-8038"},{"type":"electronic","value":"2378-8038"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1209"}}