{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:31:35Z","timestamp":1767907895577,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102314\u2010B418\u2010003"],"award-info":[{"award-number":["NSTC 112\u20102314\u2010B418\u2010003"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>This study correlated stage of Meniere's disease (MD) with MR imaging of endolymphatic hydrops (EH) to assess the role of MD staging in modern era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four MD patients (60 ears) underwent an inner ear test battery and were further confirmed by MR imaging. Sixty MD ears were divided into stages I\u2013IV, and hydrops MR images at each stage were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hydrops MRI demonstrated that EH at the cochlea with respective Grades 0\/I\/II were 3\/7\/1 ears for stage I, 0\/5\/3 ears for stage II, 1\/6\/26 ears for stage III and 0\/2\/6 ears for stage IV. Significant relationship was not identified between MD stage and grades of cochlear hydrops. Similarly, no significant relationship was shown between MD stage and grades of vestibular (saccular\/utricular) hydrops. The optimal cutoff value of four\u2010tone average for predicting severe type (Grade II\u2013III) cochlear\/vestibular EH was 48\u2009dB, which was within the stage III. Hence, prevalence of severe type (Grade II) cochlear EH in stages III (79%) and IV (75%) was significantly higher than stages I (9%) and II (38%). Similarly, severe type saccular\/utricular EH in stages III (64%) and IV (75%) also showed significantly higher than stages I (18%) and II (25%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although conventional MD staging fails to correlate with the grades of EH on hydrops MRI, late\u2010stage MD may indicate heightened EH severity in the cochlea and vestibule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1213","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T12:08:32Z","timestamp":1705320512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of conventional MD staging in modern era of hydrops MR imaging"],"prefix":"10.1002","volume":"9","author":[{"given":"Hong\u2010Yu","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-5811","authenticated-orcid":false,"given":"Yi\u2010Ho","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894830920S501","article-title":"Endolymphatic hydrops. An overview and classification","volume":"106","author":"Schuknecht HF","year":"1983","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600418"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.2.190"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.05.028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000312199"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23640"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.2012-0027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3856"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02155-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001479"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28362"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.08.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.28"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-150549"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.869"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811425884"},{"key":"e_1_2_8_19_1","first-page":"72","article-title":"The natural course of Meniere's disease","volume":"406","author":"Friburg U","year":"1984","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Meniere's disease and endolymphatic hydrops. 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