{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:35:18Z","timestamp":1770294918980,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Total laryngectomy (TL) patients are good models in which to evaluate the effects of nasal airflow cessation on the sinonasal tract. Here, we evaluated changes in sinonasal structures and association with sinus opacification in the computed tomography (CT) images 3\u2009years post\u2010TL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent TL from 2005 to 2017 in a teaching academic center were reviewed retrospectively. Patients with a final follow\u2010up CT taken less than 3\u2009years after TL, tracheoesophageal puncture, inadequate CT image, or history of sinonasal surgery were excluded. The control group included patients who underwent a partial laryngectomy or hypopharyngectomy without requiring a tracheotomy for more than a month. Altogether, 45 TL patients and 38 controls were selected. The volume of all four paranasal sinuses, inferior turbinate soft tissue volume (ITSTV), maxillary sinus natural ostium (MSNO) mucosal width, and Lund\u2013Mackay scores (LMS) were measured on preoperative and postoperative CT scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean duration between surgery and the final CT scan was 6.3\u2009\u00b1\u20092.4 and 5.5\u2009\u00b1\u20092.3\u2009years for the TL and control groups, respectively. Neither group showed significant changes in the four paranasal sinuses' volume or MSNO mucosa width. The ITSTV decreased significantly, from 4.6\u2009\u00b1\u20091.3 to 2.8\u2009\u00b1\u20091.1\u2009mL (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), in the TL group, regardless of the presence of nasal septal deviation, showing ITSTV reduction on both concave and convex sides. By contrast, the control group showed no significant changes in ITSTV. Postoperative LMS changes in both groups were insignificant. The number of patients with LMS aggravation or alleviation was the same in both groups, regardless of preoperative sinus opacification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paranasal sinus structures and sinus opacification are not affected significantly by nasal airflow cessation; however, the inferior turbinate mucosa is affected by long\u2010term discontinuation of nasal airflow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 (case\u2013control study).<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1214","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T06:24:23Z","timestamp":1705559063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of long\u2010term nasal airflow deprivation on sinonasal structures and chronic rhinosinusitis in total laryngectomy patients"],"prefix":"10.1002","volume":"9","author":[{"given":"Marn Joon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"},{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Inha University School of Medicine  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirye","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Bundang Jesaeng General Hospital, Daejin Medical Center  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Heui","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo\u2010Sam","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-0388","authenticated-orcid":false,"given":"Yong Ju","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-0254","authenticated-orcid":false,"given":"Myeong Sang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul 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