{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:33:22Z","timestamp":1783470802588,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Salivary duct carcinoma (SDC) is a rare and aggressive salivary gland malignancy. Herein, we present the largest single\u2010institution review of SDC to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study of all histologically confirmed cases of SDC seen at our institution from January 1, 2002, to August 1, 2022. Patient demographics, treatment, histological characteristics, tumor staging, and outcomes were extracted from the electronic medical record. Kaplan\u2010Meier and Cox regression survival analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 119 patients with a mean age of 66.2\u2009years. Most primary tumors arose from the parotid gland (72.3%), and 23.5% were noted to be carcinoma ex\u2010pleomorphic adenoma. 57.1% of patients presented with regional lymph node metastasis, whereas 23.5% presented with distant disease. Kaplan\u2013Meier analysis demonstrated a 62.4% 5\u2010year overall survival (OS) and a 69.0% 5\u2010year disease\u2010specific survival (DSS). Univariate analyses indicated that presence of regional lymph node disease (<jats:italic>p<\/jats:italic>&lt;.001), distant metastasis (<jats:italic>p<\/jats:italic>&lt;.001), perineural invasion (<jats:italic>p<\/jats:italic>\u2009=\u2009.027), and lymphovascular invasion (<jats:italic>p<\/jats:italic>\u2009=\u2009.018) were predictive of decreased OS and DSS. Trastuzumab administration was not associated with survival in HER\u20102\u2010positive patients receiving chemotherapy. Multivariate analyses demonstrated that presence of nodal disease (HR 30.337, 95% CI 2.782\u2013330.851, <jats:italic>p<\/jats:italic>\u2009=\u2009.005) and carcinoma ex pleomorphic adenoma (HR 5.54, 95% CI 1.024\u201329.933, <jats:italic>p<\/jats:italic>\u2009=\u2009.047) were associated with decreased OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our patients had more favorable survival rates compared to prior studies, which may be due to lower incidence of nodal disease. Factors associated with worse survival included nodal and distant metastases, perineural invasion, lymphovascular invasion, and tumor size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1234","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T10:24:30Z","timestamp":1711189470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A 22\u2010year single institution review of 119 cases of salivary duct carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-4858","authenticated-orcid":false,"given":"Ethan J.","family":"Han","sequence":"first","affiliation":[{"name":"Department of Head &amp; Neck Surgery UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-7857","authenticated-orcid":false,"given":"Laith A.","family":"Mukdad","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Surgery UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazeed","family":"Alhiyari","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Surgery UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-0129","authenticated-orcid":false,"given":"Morcos N.","family":"Nakhla","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Surgery UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti P.","family":"Sajed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-9534","authenticated-orcid":false,"given":"Maie A.","family":"St. John","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Surgery UCLA  Los Angeles California USA"},{"name":"UCLA Head and Neck Cancer Program UCLA Medical Center  Los Angeles California USA"},{"name":"Jonsson Comprehensive Cancer Center UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000436"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22288"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000413"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2014.32.3.125"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3930"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23350"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.05.005"},{"key":"e_1_2_7_10_1","unstructured":"Cancer AJCo.Salivary Gland Cancer Stages. 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