{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:59:06Z","timestamp":1753869546301,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this retrospective study was to describe the clinicopathological characteristics of primary adenoid cystic carcinoma (ACC) of the palate and to identify the factors affecting prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 85 patients with primary ACC of the palate treated with surgery, with or without adjuvant radiotherapy\/chemotherapy, from 2009 to 2019 were reviewed. The relationship of different clinical parameters with locoregional recurrence (LR), distant metastasis (DM), and overall survival (OS) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up time was 44.6\u2009months. LR and DM rates were 24.7% and 25.9%, respectively, and the 5\u2010year OS and disease\u2010free survival (DFS) rates were 85.9% and 55.1%, respectively. Multivariate analysis showed that positive margins were independently associated with the risk of LR (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Positive margins (<jats:italic>p<\/jats:italic>\u2009=\u2009.001) and high histological grade (<jats:italic>p<\/jats:italic>\u2009=\u2009.031) were significantly associated with shorter OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positive surgical margins are a strong adverse prognostic factor affecting LR and OS in patients with ACC; apart from that, high histopathological grade is an independent predictor of poor OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 3 (Prognosis \u2013 Cohort study).<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1236","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T10:24:31Z","timestamp":1711189471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic factors of palatal adenoid cystic carcinoma: A single\u2010center analysis of 85 cases"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-3056","authenticated-orcid":false,"given":"Baoxin","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center of Stomatology  Beijing China"},{"name":"National Clinical Research Center for Oral Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Chi","sequence":"additional","affiliation":[{"name":"National Center of Stomatology  Beijing China"},{"name":"National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery 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