{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:42:31Z","timestamp":1770496951871,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Otosclerosis is characterized by abnormal bone growth in the otie capsule. Nowadays, stapedotomy is commonly used for otosclerosis treatment. Currently, postoperative dizziness has been associated with stapedotomy. In 1981, intratympanic dexamethasone was utilized to manage inner ear disorders like tinnitus and acute sensorineural hearing loss. However, there is much uncertainty regarding the effect and safety of topical steroid therapy in the middle ear during stapedotomy. In the present study, we assessed the effect of topical steroid therapy during stapedotomy on postoperative dizziness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Otosclerosis patients eligible for stapedotomy were randomly divided into two groups based on dexamethasone administration or placebo. Audiometric and tympanometry results were observed and recorded for the involved frequencies. The Dizziness Handicap Inventory was used to quantify patient perceptions of dizziness and balance issues. Audiometry and dizziness assessments were repeated at discharge and 4\u2009months after the operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised 72 otosclerosis patients undergoing stapedotomy. At discharge, the intervention group showed a significant reduction in the incidence of dizziness compared to the placebo group. However, in the 4\u2010month follow\u2010up after the operation, both groups experienced a decrease in dizziness incidence, with no significant difference between them. There was also no significant difference in audiometric levels between the two groups. Interestingly, the intervention group had a significantly lower need for systemic anti\u2010dizziness drugs after surgery compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical dexamethasone during stapedotomy effectively minimizes dizziness at discharge and reduces the need for postoperative anti\u2010dizziness medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1257","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T17:53:25Z","timestamp":1715277205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post\u2010stapedotomy dizziness after applying topical steroid on footplate: A randomized controlled trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Behrouz","family":"Barati","sequence":"first","affiliation":[{"name":"Taleghani Hospital Clinical Research Development Unit Shahid Beheshti University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-8253","authenticated-orcid":false,"given":"Arvin","family":"Shahzamani","sequence":"additional","affiliation":[{"name":"Taleghani Hospital Clinical Research Development Unit Shahid Beheshti University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Goljanian","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Taleghani Hospital Clinical Research Development Unit Shahid Beheshti University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobe","family":"Asadi","sequence":"additional","affiliation":[{"name":"Taleghani Hospital Clinical Research Development Unit Shahid Beheshti University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.3221"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72962-6_1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100103846"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2022.2048071"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010023\u201008008\u20107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486818"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0926-2"},{"issue":"1","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.53730\/ijhs.v6nS1.5143","article-title":"Balance after stapedectomy","volume":"6","author":"Hamdy MM","year":"2022","journal-title":"Int J Health Sci"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.24179\/kbbbbc.2021-85624"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5631\/jibirin.75.2525"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.05.021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2017.07.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.98636"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790360050013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098849"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000261655.30652.62"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2022.2146747"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12769"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"51","article-title":"The effect of D\u2010penicillamine and methylprednisolone on the morphology of experimental granulation tissue in rats","volume":"90","author":"H\u00f8lund B","year":"1982","journal-title":"Acta Pathol Microbiol Immunol Scand A: Pathology"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05816-z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.06.002"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.1257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:13:44Z","timestamp":1731935624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.1257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/lio2.1257"],"URL":"https:\/\/doi.org\/10.1002\/lio2.1257","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"2023-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1257"}}