{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:20Z","timestamp":1791301280070,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess long\u2010term safety and effectiveness of a multipoint, impedance\u2010controlled, RF ablation device for treatment of chronic rhinitis through 12\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicenter study. Bilateral posterior nasal nerve (PNN) ablation was performed on all participants. Assessments at 6\u2010, 9\u2010, and 12\u2010month visits included Visual Analog Scale Nasal Symptom Score (VAS NSS), reflective Total Nasal Symptom Score (rTNSS), mini\u2010Rhinoconjunctivitis Quality of Life Questionnaire (mini RQLQ), and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six participants were enrolled and 35 completed the 12\u2010month follow\u2010up. All 5 VAS NSS items demonstrated statistically significant improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) over baseline at all 3 time points. The total rTNSS improved from 7.9\u2009\u00b1\u20091.8 at baseline to 4.3\u2009\u00b1\u20092.1 at 6\u2010months, 3.8\u2009\u00b1\u20092.4 at 9\u2010months, and 4.0\u2009\u00b1\u20092.1 at 12\u2010months (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). At 12\u2010months, 91% (31\/35) of participants had achieved the minimum clinically important difference (MCID) of a reduction from baseline of \u22651 point and 80% (28\/35) of the participants met the responder criteria of \u226530% reduction from baseline. The total mean mini RQLQ was reduced from 3.0\u2009\u00b1\u20091.0 at baseline to 1.4\u2009\u00b1\u20090.8 at 6\u2010months, 1.4\u2009\u00b1\u20091.0 at 9\u2010months, and 1.3\u2009\u00b1\u20090.8 at 12\u2010months (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). At 12\u2010months, 86% (30\/35) of participants achieved the MCID of a reduction from baseline of \u22650.4 points for the mini RQLQ. No related serious adverse events occurred during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Impedance\u2010controlled RF ablation of the PNN is safe and resulted in durable, significant improvement in rhinitis symptoms and quality of life through 12\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>The study is registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link> with the unique identifier of NCT05324397.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1286","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T21:36:10Z","timestamp":1717536970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term outcomes following impedance\u2010controlled radiofrequency ablation for the treatment of chronic rhinitis"],"prefix":"10.1002","volume":"9","author":[{"given":"Douglas D.","family":"Reh","sequence":"first","affiliation":[{"name":"Centers for Advanced ENT Care  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Lay","sequence":"additional","affiliation":[{"name":"Alabama Nasal and Sinus Center  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Davis","sequence":"additional","affiliation":[{"name":"ENT and Allergy Associates  Seattle and Puyallup Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Dubin","sequence":"additional","affiliation":[{"name":"Centers for Advanced ENT Care  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Specialty Physician Associates  Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-764X","authenticated-orcid":false,"given":"Ellen M.","family":"O'Malley","sequence":"additional","affiliation":[{"name":"O'Malley Medical Communications, LLC  Victoria Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sillers","sequence":"additional","affiliation":[{"name":"Alabama Nasal and Sinus Center  Birmingham Alabama 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