{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:36:07Z","timestamp":1791498967768,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Three\u2010tesla MRI with gadolinium\u2010based contrast agents is important in diagnosing M\u00e9ni\u00e8re's disease. However, contrast agents cannot be used in some patients. By using the compositional difference between the inner ear endolymph and perilymph, we performed basic and clinical research focused on potassium ions and protein to find the optimal parameters for visualizing endolymphatic hydrops on MRI without contrast. We then examined the relationship between severity stage and visualization rate of endolymphatic hydrops.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In phantom experiments simulating the endolymph and perilymph, we explored MRI parameters that could be used to separate endolymph from perilymph by gradually changing the inversion time. We then used these parameters to perform both new non\u2010contrast MRI and contrast MRI on the same day in M\u00e9ni\u00e8re's disease patients, and we compared the visualization rates of endolymphatic hydrops under the two modalities. Fifty patients were selected from 478 patients with M\u00e9ni\u00e8re's disease of different severity stages; 12 patients had asthma and allergy to contrast agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The higher the disease stage, the higher the endolymphatic hydrops visualization rate. The new non\u2010contrast MRI gave significantly higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) visualization rates of endolymphatic hydrops on the affected side in patients at Stage 3 or above than in Stages 1 and 2 combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>New non\u2010contrast MRI with parameters focusing on the endolymph\u2013perilymph difference in the density of protons surrounding the potassium ions and protein can produce images consistent with endolymphatic hydrops. We believe that this groundbreaking method will be useful for diagnosing M\u00e9ni\u00e8re's disease in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>Clinical studies are at evidence level 3 in non\u2010randomized controlled trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.1314","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T10:40:20Z","timestamp":1723286420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["New non\u2010contrast <scp>MRI<\/scp> of endolymphatic hydrops in <scp>M\u00e9ni\u00e8re's<\/scp> disease considering inversion time"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-8677","authenticated-orcid":false,"given":"Masanori","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Japan Community Healthcare Organization (JCHO) Tokyo Shinjuku Medical Center  Tokyo Japan"},{"name":"Department of Neurotology Advanced Imaging Center (AIC) Yaesu Clinic  Tokyo Japan"},{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Radiology Ochanomizu Surugadai Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Radiology Advanced Imaging Center (AIC) Yaesu Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Radiology Ochanomizu Surugadai Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"MR Clinical Science  Philips Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-8089","authenticated-orcid":false,"given":"Gail","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Head &amp; 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