{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:45Z","timestamp":1790776425565,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC013556"],"award-info":[{"award-number":["DC013556"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Disorders causing a loss of the sense of smell remain a therapeutic challenge. Basic research has, however, greatly expanded our knowledge of the organization and function of the olfactory system. This review describes advances in our understanding of the cellular components of the peripheral olfactory system, specifically the olfactory epithelium in the nose. The article discusses recent findings regarding the mechanisms involved in regeneration and cellular renewal from basal stem cells in the adult olfactory epithelium, considering the strategies involved in embryonic olfactory development and insights from research on other stem cell niches. In the context of clinical conditions causing anosmia, the current view of adult olfactory neurogenesis, tissue homeostasis, and failures in these processes is considered, along with current and future treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>NA<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.135","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T01:03:51Z","timestamp":1517879031000},"page":"35-42","source":"Crossref","is-referenced-by-count":112,"title":["Olfactory epithelium: Cells, clinical disorders, and insights from an adult stem cell niche"],"prefix":"10.1002","volume":"3","author":[{"given":"Rhea","family":"Choi","sequence":"first","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine Miami Florida U.S.A"},{"name":"Program in Neurosciences, University of Miami Miller School of Medicine Miami Florida U.S.A"},{"name":"Medical Scientist Training Program, University of Miami Miller School of Medicine Miami Florida U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-1696","authenticated-orcid":false,"given":"Bradley J.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine Miami Florida U.S.A"},{"name":"Program in Neurosciences, University of Miami Miller School of Medicine Miami Florida U.S.A"},{"name":"Department of Otolaryngology University of Miami Miller School of Medicine Miami Florida U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249168"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21350"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.006"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4191"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21669"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4723-04.2005"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21856"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90418-X"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1779-14.2014"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.171001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1418"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6813"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81387-2"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002640"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.06.007"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.06.010"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00025"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1201"},{"key":"e_1_2_4_20_1","unstructured":"GaunV ZunitchMJ LinB JangW SchwobJE.The lifespan of olfactory sensory neurons. Association for Chemoreception Sciences 39th Annual Meeting Poster #236 Bonita Springs FL 2017."},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880070061012"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6505700"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107541"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01206454"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903590103"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-12-04005.1996"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90120-7"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1882"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23653"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01175561"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90351-4"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0321-2"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0240-14.2014"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.142653"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0597"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.08.020"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6087-10.2011"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/7251"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.8.1611"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90381-Y"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.065870"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490260105"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-10-03896.1992"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20316"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.04.003"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512272112"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.009"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701333114"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22463"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-16-05082.1996"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04733"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.043"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.08.004"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.02.009"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0229"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.165"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118857109"},{"key":"e_1_2_4_60_1","first-page":"203","article-title":"The genetic aspects of primary eunuchoidism","volume":"48","author":"Kallmann F","year":"1944","journal-title":"Am J Ment Defic"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/353529a0"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1555"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707173104"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.07.013"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp112"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2860"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00005"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000193174.77321.39"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000181493.83661.CE"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/23.5.513"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/26.4.359"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26316"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816664879"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21872"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4507-09.2010"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3460"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620664114"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2307"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04102.x"},{"key":"e_1_2_4_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10650.x"},{"key":"e_1_2_4_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9364-1"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr165"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin16.248"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24390"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24340"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25245"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3028"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flio2.135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:15:14Z","timestamp":1695683714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/lio2.135"],"URL":"https:\/\/doi.org\/10.1002\/lio2.135","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}