{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:41:29Z","timestamp":1790336489395,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed tissue injury score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six pigs were anesthetized using a standard regimen. We intubated the tracheas using a standard endotracheal tube modified to include optical sensors. Animals were anesthetized for a duration of two to four hours, and their lungs were ventilated using a normoxic gas mixture. Following euthanasia, the tracheas were removed and underwent histological assessment by two independent veterinary pathologists. The histological lesions, including controls, were described and quantified, and two pathologists classified tissues according to a novel injury score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean duration of tracheal intubation was 191 minutes (SD \u00b1 41.6). In all except one animal, cuff pressures were maintained in the range of 25\u201345 cmH20. Histopathological findings in all study animals showed more extensive changes than previously described with short\u2010term intubation. Changes were seen in all mucosal layers consistent with acute, suppurative, and ulcerative tracheitis. The range of scores of the developed composite scoring system among the animals was wider than in earlier descriptions. There was a high percentage of agreement between both pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have described a novel tracheal injury score to assess pathological changes following short term intubation in a viable animal model. The scoring system distinguished between the test animals as well as controls and may be appropriate for continuing study of intubation injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.168","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T06:59:00Z","timestamp":1533884340000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mucosal injury following short\u2010term tracheal intubation: A novel animal model and composite tracheal injury score"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2124-2255","authenticated-orcid":false,"given":"Rishie","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Division of Clinical Neurosciences University of Nottingham, Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Correia","sequence":"additional","affiliation":[{"name":"Applied Optics Group, Faculty of Engineering University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6490-2412","authenticated-orcid":false,"given":"David","family":"Gardner","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham Sutton Bonington Campus Leicestershire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llorenc","family":"Grau\u2010Roma","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham Sutton Bonington Campus Leicestershire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"de Brot","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham Sutton Bonington Campus Leicestershire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hardman","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Division of Clinical Neurosciences University of Nottingham, Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Morgan","sequence":"additional","affiliation":[{"name":"Applied Optics Group, Faculty of Engineering University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics Nottingham University Hospitals NHS Trust Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13438"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198403000-00014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198808001-00001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-8-18"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"LahavY Shoffel\u2010HavakukH HalperinD.Acquired Glottic Stenosis\u2010The Ongoing Challenge: A Review of Etiology Pathogenesis and Surgical Management. 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