{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:09:17Z","timestamp":1780445357177,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K11205"],"award-info":[{"award-number":["16K11205"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to determine how the pathology altered electrically evoked auditory brainstem responses (EABRs) in patients with hearing loss by evaluating EABRs in auditory neuropathy patients with <jats:italic>OTOF<\/jats:italic> mutations comparing with various types of congenital deafness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 15 patients with congenital hearing loss, grouped according to pathology: <jats:italic>OTOF<\/jats:italic> mutations (n\u2009=\u20094), <jats:italic>GJB2<\/jats:italic> mutations (n\u2009=\u20094), <jats:italic>SLC26A4<\/jats:italic> mutations (n\u2009=\u20094), or cytomegalovirus infections (n\u2009=\u20093). EABRs were recorded when patients underwent cochlear implantation surgery. We evaluated the latencies and amplitudes of the recorded EABRs and compared them statistically between four groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EABR latencies of Wave III and Wave V, and of the interval between them, were significantly longer in the <jats:italic>OTOF<\/jats:italic> mutation group than in the <jats:italic>GJB2<\/jats:italic> and <jats:italic>SLC26A4<\/jats:italic> mutation groups (Wave III) and in all three other groups (Wave V and Wave III\u2010V latency); amplitudes were not significantly different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest <jats:italic>OTOF<\/jats:italic> mutations cause delayed (or slowed) postsynaptic neurotransmission, although the presumed mechanism involved reduced presynaptic transmission between hair cells and spiral ganglion neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Mainly a case report<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.210","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T13:26:35Z","timestamp":1537795595000},"page":"388-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elongated EABR wave latencies observed in patients with auditory neuropathy caused by <i>OTOF<\/i> mutation"],"prefix":"10.1002","volume":"3","author":[{"given":"Makoto","family":"Hosoya","sequence":"first","affiliation":[{"name":"National Institute of Sensory Organs  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiro B.","family":"Minami","sequence":"additional","affiliation":[{"name":"National Institute of Sensory Organs  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Enomoto","sequence":"additional","affiliation":[{"name":"National Institute of Sensory Organs  Tokyo 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