{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:53:09Z","timestamp":1790873589095,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cleft lip and palate are common craniofacial deformities. The etiology underlying these deformities is complex and multifactorial and they can occur as part of one of many chromosomal syndromes, Mendelian single gene disorders, teratogenic effects, and as yet uncharacterized syndromes. Our paper will provide an overview of the multiple genes and molecular pathways that have been implicated in palatal fusion. We believe that understanding the molecular mechanisms of cleft formation can help clinicians anticipate which patients may have difficulties healing and in the future allow them to make surgical and medical treatment decisions based on genetic information.<\/jats:p>","DOI":"10.1002\/lio2.214","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T19:21:38Z","timestamp":1542309698000},"page":"160-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Cellular and molecular mechanisms of cleft palate development"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-2864","authenticated-orcid":false,"given":"Anita S.","family":"Deshpande","sequence":"first","affiliation":[{"name":"From the Department of Otolaryngology\u2013Head and Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Goudy","sequence":"additional","affiliation":[{"name":"From the Department of Otolaryngology\u2013Head and Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"216","article-title":"Incidence of cleft lip, cleft palate, and cleft lip and palate among races: a review","volume":"24","author":"Vanderas AP","year":"1987","journal-title":"Cleft Palate J"},{"key":"e_1_2_11_3_1","first-page":"16","article-title":"Etiology of facial clefts: prospective evaluation of 428 patients","volume":"25","author":"Jones MC","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_11_4_1","first-page":"306","article-title":"Syndromes with cleft lip and cleft palate","volume":"15","author":"Cohen MM","year":"1978","journal-title":"Cleft Palate J"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57187"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199605)53:5<309::AID-TERA5>3.0.CO;2-W"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33702"},{"key":"e_1_2_11_8_1","first-page":"429","volume-title":"Larsen's Human Embryology","author":"Schoenwolf GCB SB","year":"2015"},{"key":"e_1_2_11_9_1","first-page":"313","volume-title":"Langman's Medical Embryology","author":"Sadler TW","year":"1990"},{"key":"e_1_2_11_10_1","volume-title":"GeneReviews(R)","author":"Robin NH","year":"1993"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603730103"},{"key":"e_1_2_11_12_1","volume-title":"GeneReviews(R)","author":"Katsanis SH","year":"1993"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.7.4.17926"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.2.133"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/137823"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20042133"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00585-3"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24225"},{"key":"e_1_2_11_19_1","volume-title":"GeneReviews(R)","author":"Loeys BL","year":"1993"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.6.2195"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-409"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00484.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.0010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.028167"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16531"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0295-165"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0994-98"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-462"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2016.59.3.187"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163598428275"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.17.4135"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00375"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0494-348"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng985"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181ec6aad"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00721"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1415"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00241"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2010.03.001"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/85845"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2150-7"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1903"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1894"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.02.002"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2004.1475"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flio2.214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:28:19Z","timestamp":1694651299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/lio2.214"],"URL":"https:\/\/doi.org\/10.1002\/lio2.214","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"2018-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}