{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:45:22Z","timestamp":1775245522199,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective (s)<\/jats:title>\n                    <jats:p>Energy emitting, active middle ear implants (aMEI) have taken more than two decades of research to reach technological sophistication, medical safety, and regulatory approval to become a powerful tool in treating sensorineural, conductive, and mixed hearing loss. The present review covers this era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Source<\/jats:title>\n                    <jats:p>Literature found from searching Pubmed (MEDLINE); EMBASE, SciSearch, German Medical Science Journals and Meetings, and The Cochrane Library; and published as of February 2017. Study bibliographies were hand\u2010searched to find further materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted to identify studies evaluating the safety, efficacy, effectiveness, and subjective outcomes of partially implantable aMEIs. Data were extracted on systems with regulatory approval and summarized narratively. Meta\u2010analyses were conducted for aMEIs with more than 25 publications. Study selection, data extraction, and quality appraisal for quantitative data synthesis was carried out by two reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four hundred thirty\u2010one studies included in narrative synthesis describe that albeit good audiological outcomes, clinical safety and (dis)investment are major barriers to continued market access. The synthesised risk of adverse events was three fold with the MET than with the VIBRANT SOUNDBRIDGE. With the latter system, audiological outcomes were stable and similar for all indications and age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To date, the majority of the literature covers the clinical application of the VIBRANT SOUNDBRIDGE system as it is applicable to a wide range of otologic and audiological conditions, particularly with the introduction of couplers to extend its clinical reach. The MAXUM and MET still have to find their way into surgical routine.<\/jats:p>\n                    <jats:p>Level of Evidence:<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.215","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T07:25:15Z","timestamp":1538810715000},"page":"394-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The development of active middle ear implants: A historical perspective and clinical outcomes"],"prefix":"10.1002","volume":"3","author":[{"given":"Melodi Ko\u015faner","family":"Klie\u00df","sequence":"first","affiliation":[{"name":"From the Health Economics and Health Technology Assessment Hospital of the University of Berlin, Charit\u00e9 Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-2578","authenticated-orcid":false,"given":"Arne","family":"Ernst","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow Glasgow Scotland, UK"},{"name":"the Department of Otolaryngology at UKB Hospital of the University of Berlin, Charit\u00e9 Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow Glasgow Scotland, UK"},{"name":"the Department of Otolaryngology at UKB Hospital of the University of Berlin, Charit\u00e9 Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Mittmann","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow Glasgow Scotland, UK"},{"name":"the Department of Otolaryngology at UKB Hospital of the University of Berlin, Charit\u00e9 Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"128","article-title":"An implantable hearing aid. 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