{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:01:30Z","timestamp":1760385690489,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cancer cachexia affects up to over 50% of advanced head and neck cancer (HNC) patients. To date, the potential utility of anabolic steroids in perioperative cachectic HNC patients has not been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of pre\u2010 and post\u2010oxandrolone administration prealbumin levels in 18 perioperative HNC patients between October 2007 and October 2014 at a tertiary academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median pretreatment prealbumin was 88.5\u2009mg\/L. The median post\u2010treatment prealbumin was 227\u2009mg\/L. The median interval improvement of the prealbumin level was 131.5\u2009mg\/L. The median differences between the pretreatment and post\u2010treatment prealbumin levels were found to be statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Subjective improvement in wound healing was also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perioperative administration of oxandrolone resulted in objective improvements in prealbumin levels and subjective improvements in surgical wounds. Oxandrolone administered 10\u2009mg twice daily (BID) for 10\u2009days may be a useful adjunct in the perioperative care of nutritionally deficient HNC patients who are at risk for or have demonstrated impaired wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.268","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T09:14:12Z","timestamp":1557911652000},"page":"314-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does perioperative oxandrolone improve nutritional status in patients with cachexia related to head and neck carcinoma?"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-549X","authenticated-orcid":false,"given":"Angela M.","family":"Osmolak","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Oklahoma  Oklahoma City Oklahoma U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristine N.","family":"Klatt\u2010Cromwell","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Oklahoma  Oklahoma City Oklahoma U.S.A."},{"name":"Department of Otolaryngology Head and Neck Surgery Washington University in St. Louis  St. Louis Missouri U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber M.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Oklahoma  Oklahoma City Oklahoma U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Sanclement","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Oklahoma  Oklahoma City Oklahoma U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg A.","family":"Krempl","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Oklahoma  Oklahoma City Oklahoma U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.026"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"188","article-title":"Diagnostic criteria for cancer cachexia: data versus dogma","volume":"19","author":"Martin L","year":"2016","journal-title":"Curr Opin Clin Nutr Metab 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