{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:50:58Z","timestamp":1778694658571,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Competitive Research Funding of the Tampere Medical Research Fund of Tampere University Hospital"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Finnish Association of Otorhinolaryngology and Head and Neck Surgery"},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"crossref"}]},{"name":"V\u00e4in\u00f6 and Laina Kivi Foundation"},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnsson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is a variable multifactorial disease. It can be divided into forms with nasal polyps (CRSwNP) and without (CRSsNP). Sinus and\/or nasal polypectomy surgery are considered if maximal conservative treatment is insufficient. The predictive factors of the need of revision surgery comprise mostly the CRSwNP phenotype and are not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>The aim of this follow\u2010up study was to evaluate the factors associated with the revision surgery rate in CRS patients with variable extent of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of CRS patients (N\u2009=\u2009178) undergoing sinus surgery and\/or nasal polypectomy in 2001 to 2010 were used. Patient characteristics and follow\u2010up data were collected from patient records and questionnaires. Associations were analyzed by Fisher's exact, Mann Whitney U, and the Kaplan\u2010Meier method with log\u2010rank test. Unadjusted Cox's proportional hazard models were used for 12 variables and were fitted for the need for revision sinus surgery and\/or nasal polypectomy during follow\u2010up of in average 9 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of CRS patients who had undergone revision in 5 years was 9.6%. After adjustment, the following factors associated significantly with the need for recurrent CRS surgery: allergic rhinitis, corticosteroid treatment, previous surgery of CRS, and recurrent NP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased risk of progressive CRS phenotypes with the need for revision surgery would putatively be recognized by relatively simple clinical questions. Further studies with increased sample size are needed to evaluate whether these predictive factors would be relevant for developing better detection and management of progressive CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.27","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T07:02:59Z","timestamp":1467702179000},"page":"96-105","source":"Crossref","is-referenced-by-count":34,"title":["Factors affecting revision rate of chronic rhinosinusitis"],"prefix":"10.1002","volume":"1","author":[{"given":"Anni","family":"Koskinen","sequence":"first","affiliation":[{"name":"Haartman Institute, University of Helsinki (a.k., r.s., r.r., s.t\u2010s.)"},{"name":"the Department of Otorhinolaryngology (a.k.); University of Helsinki and Helsinki University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riikka","family":"Salo","sequence":"additional","affiliation":[{"name":"Haartman Institute, University of Helsinki (a.k., r.s., r.r., s.t\u2010s.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"the School of Health Sciences, (h.h.); Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyri","family":"Myller","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology P\u00e4ij\u00e4t\u2010H\u00e4me Central Hospital (j.m.) 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University of Helsinki and Helsinki University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Toppila\u2010Salmi","sequence":"additional","affiliation":[{"name":"Haartman Institute, University of Helsinki (a.k., r.s., r.r., s.t\u2010s.)"},{"name":"the Department of Allergy (m.m., s.t\u2010s.) 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