{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:37:37Z","timestamp":1778503057162,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Subglottic stenosis (SGS) is a serious, potentially life\u2010threatening disorder that is difficult to treat due to significant recurrence rates. While conventional treatment of SGS relies heavily on serial endoscopic dilation procedures, this study aims to characterize the efficacy of incorporating subglottic corticosteroid injections in increasing surgery\u2010free intervals (SFIs) for a cohort of patients at a university\u2010based medical system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All SGS patients who underwent endoscopic dilation and at least one adjuvant office\u2010based serial intralesional steroid injection (SILSI) were reviewed. Patients were excluded if they had synchronous airway lesions or stenosis outside of the subglottis. Charts were reviewed for demographic and treatment\u2010specific data. The SFI was calculated for patients both prior to the initiation of SILSI and after. Groups were compared via Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, with <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05 as the threshold for significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients met criteria, with mean age 50.1\u2009\u00b1\u200914.1\u2009years and 7:6 female\u2009to\u2009male ratio. Eight of the thirteen (61.5%) had intubation\u2010related stenosis, while 4\/13 were idiopathic and 1\/13 was due to Wegener's granulomatosis. Mean follow\u2010up was 20.4\u2009months. Patients underwent an average of 4.2\u2009\u00b1\u20092.2 postoperative injections, beginning 45.9\u2009\u00b1\u200919.0\u2009days after surgery. The mean SFI prior to initiating SILSI was 288.6\u2009\u00b1\u2009362.0\u2009days; while after receiving SILSI, the mean interval was significantly longer (545.5\u2009\u00b1\u2009152.7\u2009days, <jats:italic>P<\/jats:italic> = .0041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrate that office\u2010based corticosteroid injection for SGS was associated with a statistically significant improvement in the SFI and is a promising adjuvant approach. Future prospective studies should evaluate if the efficacy is reproducible on a large scale and if SILSI can and\/or should be incorporated into the standard management paradigm for SGS treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.284","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T13:49:26Z","timestamp":1560174566000},"page":"414-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Office\u2010based corticosteroid injections as adjuvant therapy for subglottic stenosis"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-0340","authenticated-orcid":false,"given":"Debbie R.","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-0158","authenticated-orcid":false,"given":"David E.","family":"Rosow","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Miller School of Medicine  Miami Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116001122"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21121"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000305"},{"issue":"4","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"e022243","DOI":"10.1136\/bmjopen-2018-022243","article-title":"Treatment options in idiopathic subglottic stenosis: protocol for a prospective international multicenter pragmatic 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