{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:39:36Z","timestamp":1781649576985,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) has an impact on health\u2010related quality of life (HRQOL). The objective of this study was to examine generic and disease\u2010specific HRQOL and symptoms in CRS patients with (CRSwNP) and without (CRSsNP) nasal polyps before and 6\u2009months after sinus surgery, and to identify preoperative patient factors associated with HRQOL outcome in the two groups separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational study consisted of 220 CRSwNP and 196 CRSsNP patients. Generic and disease\u2010specific HRQOL were measured using the Short\u2010Form\u2010Health\u2010Survey (SF\u201036) and Sino\u2010Nasal\u2010Outcome\u2010Test (SNOT\u201020). Symptoms were assessed on a visual analog scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperatively, CRSwNP patients reported worse score in general health (SF\u201036), rhinologic subset (SNOT\u201020): nasal obstruction, nasal discharge, and altered sense of smell compared to CRSsNP patients, who reported worse score in physical role, bodily pain, ear\/face subset, and facial pain. After surgery, generic and disease\u2010specific HRQOL and symptoms improved in both groups. CRSwNP patients had greater improvement in general health, vitality and social function, nasal obstruction, and altered sense of smell, compared to CRSsNP\u2010patients. In both groups, higher age, daily smoking, and having had sinus surgery previously were associated with less generic HRQOL improvement, in addition to female sex and allergy in CRSsNP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The greater improvement in general health, vitality, and social function after surgery may indicate a greater potential for generic HRQOL improvement in CRSwNP patients compared to CRSsNP patients. Female sex and allergy was associated with less improvement of generic HRQOL in the CRSsNP group, but not in the CRSwNP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>2c outcome research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.299","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T10:44:03Z","timestamp":1565606643000},"page":"476-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["General health, vitality, and social function after sinus surgery in chronic rhinosinusitis"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4173-4049","authenticated-orcid":false,"given":"Ann Helen","family":"Nilsen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery St Olav's University hospital of Trondheim  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sofie","family":"Helvik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery St Olav's University hospital of Trondheim  Trondheim Norway"},{"name":"Department of Public Health and Nursing Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenche Moe","family":"Thorstensen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery St Olav's University hospital of Trondheim  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Salvesen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vegard","family":"Bugten","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery St Olav's University hospital of Trondheim  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3981"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02709.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.3.320"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3054-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27227"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12665"},{"key":"e_1_2_8_8_1","first-page":"305","article-title":"Impact of chronic rhinosinusitis therapy on quality of life: a prospective randomized controlled trial","volume":"48","author":"Ragab SM","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_8_9_1","first-page":"40","article-title":"Chronic rhinosinusitis and nasal polyposis; indicia of heterogeneity","volume":"46","author":"Bugten V","year":"2008","journal-title":"Rhinology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2017.31.4446"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12901-016-0030-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2626-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.033"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_8_19_1","first-page":"Cd006991","article-title":"Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps","volume":"12","author":"Rimmer J","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_8_21_1","unstructured":"SF\u201036v2\u00ae Health Survey \u00a9 1994\u20102012. Medical Outcomes Trust and QualityMetric Incorporated. All rights reserved. S\u2010iartoMO Trust. SF\u201036v2\u00ae Health Survey Standard NN. Short Form Health Survey 36 2012."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_8_23_1","volume-title":"User's manual for the SF\u201036v2 Health Survey","author":"Ware JE","year":"2011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.4.5.581"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.024"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.5.1208"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000184581.67185.6e"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000241362.06072.83"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0501-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino11.101"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.09.020"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0625-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1684-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2007.11.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812451408"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25318"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2979"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3005"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T14:31:54Z","timestamp":1694183514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/lio2.299"],"URL":"https:\/\/doi.org\/10.1002\/lio2.299","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]},"assertion":[{"value":"2019-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}