{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:46:52Z","timestamp":1782370012492,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Structured histopathology reporting has been recently described for detailing immunopathological characteristics of chronic rhinosinusitis (CRS), and can be utilized for subtyping CRS and personalizing management. This study scrutinized elements of structured histopathology to identify characteristics that prognosticate outcomes following endoscopic sinus surgery (ESS) for CRS patients with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcomes following ESS were measured using the patient\u2010reported 22\u2010item sinonasal outcome test (SNOT\u201022). Changes in total SNOT\u201022 scores at 6 and 12\u2009months postoperatively were analyzed. Thirteen parameters reported in structured histopathology of sinus surgical tissue were studied for association with outcomes postsurgery. The overall cohort of all CRS patients was studied, along with subgroup analyses of CRSwNP and CRSsNP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the entire CRS cohort (n = 171), eosinophil count &gt;10 per high power field (HPF) was associated with greater improvement in SNOT\u201022 scores at 6\u2009months post\u2010ESS (<jats:italic>P<\/jats:italic> = .039). At 12\u2009months follow\u2010up, no histopathological characteristic was associated with change in total SNOT\u201022 score. In the CRSwNP (n = 66) subgroup, the presence of fibrosis (<jats:italic>P<\/jats:italic> = .006) and eosinophil count \u226410 per HPF (<jats:italic>P<\/jats:italic> = .025) were associated with less favorable changes in SNOT\u201022 scores at 12\u2009months follow\u2010up. Fibrosis remained statistically significant in multivariable analysis (<jats:italic>P<\/jats:italic> = .007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 6\u2009months post\u2010ESS, tissue eosinophilia is associated with significantly higher improvement in SNOT\u201022 scores, but this difference is diluted by 12\u2009months. Fibrosis was associated with less favorable outcomes in SNOT\u201022 scores for CRSwNP patients at 12\u2009months and may be a prognosticator for poorer long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.303","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T09:41:05Z","timestamp":1566380465000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A structured histopathology\u2010based analysis of surgical outcomes in chronic rhinosinusitis with and without nasal polyps"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-0310","authenticated-orcid":false,"given":"Michael J.","family":"Marino","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic  Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Omar","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic  Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Zarka","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Mayo Clinic  Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devyani","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic  Phoenix Arizona 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