{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:14:07Z","timestamp":1791656047533,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Administration of botulinum toxin through intraductal salivary infusion may decrease the risks of percutaneous needle injection and improve delivery to permeate the entire gland parenchyma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The safety of intraductal salivary gland infusion was tested with prospective evaluation of two patients using interviews, clinical examination, and pressure measurement during infusion. Retrospective chart review of two subsequently treated patients assessed treatment of a parotid\u2010cutaneous fistula and sialorrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No complications were identified in the safety study. Pressure changes during infusion supported the concept of botulinum neurotoxin delivery to permeate the gland. Patient\u2010assessed success was subjectively reported as a reduction in the parotid\u2010cutaneous output \u201cby 95%\u201d and the sialorrhea \u201cby 90%\u201d at 2\u2010week follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The intraductal route of botulinum toxin delivery to salivary glands was without complication and was effective in two patients treated therapeutically. Pressure measurements during infusion may be helpful to direct treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.306","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T19:52:03Z","timestamp":1567540323000},"page":"520-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Intraductal Salivary Gland Infusion With Botulinum Toxin"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-6474","authenticated-orcid":false,"given":"Adam T.","family":"Schwalje","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Iowa Hospitals and Clinics  Iowa City Iowa U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-855X","authenticated-orcid":false,"given":"Henry T.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Iowa Hospitals and Clinics  Iowa City Iowa U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10100396"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9110356"},{"key":"e_1_2_6_4_1","unstructured":"Approvals of FDA\u2010regulated products action date 07\/03\/2018 Xeomin \u00ae(incobotuinumtoxinA) highlights of prescribing information. 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