{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:27:07Z","timestamp":1789194427366,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reconstruction of segmental mandibular defects remains a challenge for the reconstructive surgeon, from both a functional and an esthetic point of view.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This clinical review examines the different techniques currently in use for mandibular reconstruction as related to a range of etiologies, including the different bone donor sites, the alternatives to free flaps (FFs), as well as the contribution of computer\u2010assisted surgery. Recent progress and the perspectives in bone tissue engineering (BTE) are also discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Osseous FF allows reliable and satisfying outcomes. However, locoregional flap, distraction osteogenesis, or even induced membrane techniques are other potential options in less favorable cases. Obtaining an engineered bone with satisfactory mechanical properties and sufficient vascular supply requires further investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Osseous FF procedure remains the gold standard for segmental mandible reconstruction. BTE strategies offer promising alternatives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.325","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T02:30:12Z","timestamp":1574476212000},"page":"587-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Reconstruction of segmental mandibular defects: Current procedures and perspectives"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-5077","authenticated-orcid":false,"given":"Arnaud","family":"Par\u00e9","sequence":"first","affiliation":[{"name":"Service de Chirurgie Maxillo Faciale Plastique et Brul\u00e9s, H\u00f4pital Trousseau, CHU de Tours  Tours France"},{"name":"Laboratoire Regenerative Medicine and Skeleton RMeS, France INSERM, U 1229  Nantes France"},{"name":"UFR M\u00e9decine Universit\u00e9 de Tours  Tours France"},{"name":"UFR Odontologie Universit\u00e9\u0301 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Bossard","sequence":"additional","affiliation":[{"name":"ONIRIS Nantes\u2010Atlantic College of Veterinary Medicine Centre de Rechecherche et D'investigation Pr\u00e9clinique (CRIP)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Laure","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo Faciale Plastique et Brul\u00e9s, H\u00f4pital Trousseau, CHU de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Weiss","sequence":"additional","affiliation":[{"name":"Laboratoire Regenerative Medicine and Skeleton RMeS, France INSERM, U 1229  Nantes France"},{"name":"UFR Odontologie Universit\u00e9\u0301 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Laboratoire Regenerative Medicine and Skeleton RMeS, France INSERM, U 1229  Nantes France"},{"name":"ONIRIS Nantes\u2010Atlantic College of Veterinary Medicine Centre de Rechecherche et D'investigation Pr\u00e9clinique (CRIP)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Corre","sequence":"additional","affiliation":[{"name":"Laboratoire Regenerative Medicine and Skeleton RMeS, France INSERM, U 1229  Nantes France"},{"name":"UFR Odontologie Universit\u00e9\u0301 de Nantes  Nantes France"},{"name":"Service de Chirurgie Maxillo\u2010Faciale et Stomatologie CHU de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.46.113"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.12.020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23815"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001106"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182402d9a"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318221dc2a"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.050"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16935-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.07.013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2017.01.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2017.06.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.09.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24395"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2017.09.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.10.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-015-0766-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00727"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30418"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.01.023"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.04.013"},{"issue":"7","key":"e_1_2_9_23_1","first-page":"1266","article-title":"Classification of mandibular defects","volume":"92","author":"Boyd JB","year":"1993","journal-title":"Plast Reconstr Surg"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870190045010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00310-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004239"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25606"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4246-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1677791"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000454"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.05.051"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24539"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181b98b78"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181d62aef"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890180078018"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20776"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000065911.00623.BD"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90165-8"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000282"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2017.06.003"},{"issue":"3","key":"e_1_2_9_41_1","first-page":"346","article-title":"Reconstruction of the long bones by the induced membrane and spongy autograft","volume":"45","author":"Masquelet AC","year":"2000","journal-title":"Ann Chir Plast Esthet"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stomax.2012.05.008"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000187170.48370.76"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.03.020"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.07.021"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.05.020"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.06.015"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000475796.61855.a7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(08)70003-2"},{"issue":"2","key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/SCS.0000000000004119","article-title":"Mandibular reconstruction using a customized three\u2010dimensional titanium implant applied on the lingual surface of the mandible","volume":"29","author":"Jo Y\u2010Y","year":"2018","journal-title":"J Craniofac Surg"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(15)30055-3"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.05.037"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518767120"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.07.005"},{"key":"e_1_2_9_55_1","first-page":"278","article-title":"Design variables for mechanical properties of bone tissue scaffolds","volume":"42","author":"Howk D","year":"2006","journal-title":"Biomed Sci Instrum"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2017.10.001"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JMSM.0000004006.90399.b4"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199707)36:1<17::AID-JBM3>3.0.CO;2-O"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514547763"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.09.013"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632702753503045"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12123.x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000200069.81973.49"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.07.012"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2012.08.015"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.09.008"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000201424.27509.72"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0028"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004779"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.10.027"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.01.010"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.10.013"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.173"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324408"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492417"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328211402243"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.11.025"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1164-5-2"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.10.018"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2336"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-012-1550-3"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.08.025"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:06:49Z","timestamp":1694174809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/lio2.325"],"URL":"https:\/\/doi.org\/10.1002\/lio2.325","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]},"assertion":[{"value":"2019-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}