{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:33:07Z","timestamp":1747150387662,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This pilot study evaluated the long\u2010term outcomes of patients with advanced T2 or T3 squamous cell carcinoma of the larynx (SCC\u2010L) who were treated with selective intra\u2010arterial cisplatin and concomitant radiotherapy (RADPLAT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively investigated the data of 49 patients with advanced T2 or T3 SCC\u2010L who received a RADPLAT regimen with low\u2010dose cisplatin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year locoregional control, disease\u2010specific survival, and overall survival rates were 83.3%, 88.1%, and 82.6%, respectively, while the 5\u2010year freedom from laryngectomy, laryngectomy\u2010free survival, and laryngo\u2010esophageal dysfunction\u2010free survival rates were 89.6%, 79.4%, and 77.1%, respectively. The incidences of grade 3\u20104 hematologic and nonhematologic toxicities were 18% and 6%, respectively. Although two patients (4%) developed late toxicities within 5\u2009years following RADPLAT, no other events were noted beyond 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study demonstrated that RADPLAT is feasible and safe and yielded favorable survival outcomes and functional laryngeal preservation in patients with advanced T2 or T3 SCC\u2010L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.346","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T15:29:28Z","timestamp":1578497368000},"page":"55-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Organ preservation following radiation therapy and concurrent intra\u2010arterial low dose cisplatin infusion for advanced T2 and T3 laryngeal cancer: Long\u2010term clinical results from a pilot 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