{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:56:48Z","timestamp":1788580608746,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transoral laser microsurgery has been suggested as an alternative treatment modality for hypopharyngeal carcinoma. The purpose of this study is to systematically review the oncologic and functional outcomes of patients with hypopharyngeal carcinoma when treated with primary transoral laser microsurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was performed using PRISMA methodology on OVID MEDLINE and EMBASE. Meta\u2010analysis was completed for oncological outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies reported quality of life outcomes five reported oncologic outcomes. A median of 95% (range 0.83\u20100.98) patients achieving gastrostomy independence, a median of 3% (range 0%\u20106%) were tracheostomy dependent, and a median of 97% (Range 0.89\u20101.0) were able to preserve their larynx. Pooled five\u2010year overall survival was 54% (CI, 0.50\u20100.58, I<jats:sup>2<\/jats:sup> =\u200929%), pooled disease\u2010specific survival was 72% (CI, 0.68\u20100.77, I<jats:sup>2<\/jats:sup> =\u200946%), and pooled local control rate was 78% (CI, 0.72\u20100.85, I<jats:sup>2<\/jats:sup> =\u200969%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systematic review supports improvements in functional outcomes and oncologic outcomes with transoral laser microsurgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.351","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T17:42:44Z","timestamp":1579023764000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Systematic review and meta\u2010analysis of transoral laser microsurgery in hypopharyngeal carcinoma"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-050X","authenticated-orcid":false,"given":"Ciaran","family":"Lane","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasheda","family":"Rabbani","sequence":"additional","affiliation":[{"name":"George &amp; Fay Yee Center for Healthcare Innovation, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-9022","authenticated-orcid":false,"given":"Janice","family":"Linton","sequence":"additional","affiliation":[{"name":"Neil John Maclean Health Sciences University of Manitoba Libraries  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Mark","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Dalhousie University  Halifax Regional Municipality Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Viallet","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Cummings Otolaryngology Head & Neck Surgery","author":"Flint PW","year":"2010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225936.88411.71"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900090073010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24915"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199609\/10)18:5<405::AID-HED3>3.0.CO;2-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24651"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1694-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.890"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20427"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.111597"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815aeda3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.2.139"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23291"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39057.406644.68"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184"},{"key":"e_1_2_8_19_1","unstructured":"Centre CTNC. 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