{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:49:15Z","timestamp":1768888155642,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the surgical results and complications in a cohort of patients operated on to repair a tegmen bony defect using either transmastoid approach with obliteration using S53P4 bioactive glass granules (TMA\u2010O), or the classic middle cranial fossa approach (MCFA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>A retrospective monocentric study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five cases (24 patients) were included. Data regarding patient demographics, etiology, intraoperative findings, complications, recurrences, audiometric data, and follow\u2010up were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients were operated with MCFA and 17 patients with TMA\u2010O. One patient was operated on using a combined approach (MCFA + TMA\u2010O). In the preoperative HRCT scan, the size of the defect was estimated to be 6\u2009\u00b1\u20093.8\u2009mm in the TMA\u2010O group and 6\u2009\u00b1\u20093.5\u2009mm in the MCFA group (<jats:italic>P<\/jats:italic>= .969). Intraoperatively, in the MCFA group, the location of the defect was mostly anterior (86%) with an intact ossicular chain (86%). A discontinuous chain was observed in 15 patients (88%) in the TMA\u2010O group. The mean follow\u2010up time was 22\u2009\u00b1\u200914\u2009months in the TMA\u2010O group and 24\u2009\u00b1\u200915\u2009months in the MCFA group (<jats:italic>P<\/jats:italic>= .762). In both groups, there were no early postoperative complications or recurrences during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repair of a tegmen bony defect with S53P4 bioactive glass granules seems to be safe and effective, limiting the use of the middle cranial fossa approach to cases with epitympanic defects and with an intact ossicular chain, and it could be used whatever the size of the defect and\/or the presence of meningoencephalocele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.374","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T13:29:30Z","timestamp":1583760570000},"page":"297-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management of tegmen defects with mastoid and epitympanic obliteration using S53P4 bioactive glass"],"prefix":"10.1002","volume":"5","author":[{"given":"Fran\u00e7oise","family":"Remangeon","sequence":"first","affiliation":[{"name":"APHP D\u00e9partement d'Otologie, d'implants auditifs et de base du cr\u00e2ne, auditory Groupe Hospitalo\u2010Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-045X","authenticated-orcid":false,"given":"Ghizlene","family":"Lahlou","sequence":"additional","affiliation":[{"name":"APHP D\u00e9partement d'Otologie, d'implants auditifs et de base du cr\u00e2ne, auditory Groupe Hospitalo\u2010Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauranne","family":"Alciato","sequence":"additional","affiliation":[{"name":"APHP D\u00e9partement d'Otologie, d'implants auditifs et de base du cr\u00e2ne, auditory Groupe Hospitalo\u2010Universitaire 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