{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:21:42Z","timestamp":1788542502100,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The tongue is an essential organ for human interaction, communication and survival. To date, there is a paucity of objective functional, patient reported, or quality of life outcomes of patients undergoing a total glossectomy with preservation of the larynx (TGLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine prospectively collected objective, self\u2010reported functional and quality of life (QOL) data in patients undergoing TGLP and free flap reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen TGLP patients were identified in the prospective head and neck cancer and functional outcomes database between January of 2009 and December 2017. Data collection included patient age, sex, performance status, TNM staging, diagnosis and adjuvant treatment. Swallowing and speech functions were measured and prospectively recorded pre\u2010 and postoperatively. Patient reported outcomes were measured with the Speech Handicap Index (SHI) and the M.D. Anderson Dysphagia Inventory (MDADI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had a significant reduction in their objective swallowing (<jats:italic>P<\/jats:italic> = 0.035), sentence (<jats:italic>P<\/jats:italic> = 0.001) and word intelligibility (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) scores. There was no significant reduction in SHI or total MDADI scores. All patients maintained their QOL in the post\u2010treatment time frame. There was no relationship between free\u2010flap type and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Total glossectomy with laryngeal sparing and free flap reconstruction results in significant reduction in objective functional measurements, but patients report stable functional and quality of life outcomes after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.435","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T21:39:26Z","timestamp":1597441166000},"page":"853-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Functional &amp; Quality of Life Outcomes of Total Glossectomy with Laryngeal Preservation"],"prefix":"10.1002","volume":"5","author":[{"given":"Justin M.","family":"Pyne","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Dziegielewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-6547","authenticated-orcid":false,"given":"Gabriela","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Institute for Reconstructive Sciences in Medicine Caritas Health Group  Edmonton Alberta Canada"},{"name":"Communication Sciences and Disorders University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Dzioba","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W. J.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz M.","family":"Makki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Otolaryngology Head &amp; Neck Surgery King Faisal Specialist Hospital &amp; Research Center  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hearn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7661-5277","authenticated-orcid":false,"given":"Vincent L.","family":"Biron","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8939-1364","authenticated-orcid":false,"given":"Hadi","family":"Seikaly","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.11.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0229-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.05.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20694"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0184-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181c46692"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.09.056"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.8.857"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20953"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2005.02.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.12.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28064"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20795"},{"issue":"7","key":"e_1_2_7_18_1","first-page":"870","article-title":"The development and validation of a dysphagia\u2010specific quality\u2010of\u2010life questionnaire for patients with head and neck cancer: The M. 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