{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:18:09Z","timestamp":1777393089774,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,10]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Determine if chronic rhinosinusitis (CRS) is associated with systemic hypoxemia.<\/jats:p><\/jats:sec>Methods<\/jats:title>Outpatient otolaryngology visits for 12\u2009months were analyzed, identifying patients with a diagnosis of CRS, without a comorbid diagnosis of pulmonary disease, and an oxygen saturation measurement within 14\u2009days of the otolaryngology visit. Oxygen saturation (SpO2<\/jats:sub>) measures (average SpO2<\/jats:sub>, minimum SpO2<\/jats:sub> and proportion abnormal SpO2<\/jats:sub>) were compared between CRS patients (with nasal polyps [NP] and without NP) and a control cohort of otology patients, also without pulmonary disease with univariate and multivariate analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 640 unique CRS patients with 3105 encounters, the mean and minimum SpO2<\/jats:sub> measurements were 97.6% (97.5%\u201097.7%) and 97.3% (97.2%\u201097.5%), respectively. Among 3613 control patients with 25\u2009073 encounters, the mean and minimum SpO2<\/jats:sub> measurements were 97.3% (97.3%\u201097.4%) and 97.1% (97.1%\u201097.2%), respectively. When comparing mean and minimum SpO2<\/jats:sub> among CRSsNP (97.5% and 97.2%), CRScNP (97.3% and 97.0%) and control patients (97.3% and 97.1%), no statistically significant differences were found among the 3 groups in mean and minimum SpO2<\/jats:sub> adjusting for age and sex (P<\/jats:italic> = .183 and P<\/jats:italic> = .464, respectively, ANOVA). With respect to the presence of an abnormally low oxygen saturation (SpO2<\/jats:sub>\u2009\u2264\u200994%), 4.4% of the CRSsNP, 10.9% of the CRScNP and 7.3% of the control patients demonstrated a low oxygen saturation (P<\/jats:italic> = .013).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CRS alone does not objectively contribute to systemic hypoxemia, although a subset of CRScNP patients may have abnormally low SpO2<\/jats:sub>, possibly warranting SpO2<\/jats:sub> assessment in this group of patients.<\/jats:p><\/jats:sec>Level of evidence<\/jats:title>3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.467","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:46:38Z","timestamp":1601469998000},"page":"809-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does chronic rhinosinusitis relate to systemic hypoxemia?"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-5824","authenticated-orcid":false,"given":"Neil","family":"Bhattacharyya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.019"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3499"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21615"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.11.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3613"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.09.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4252"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:14:46Z","timestamp":1693851286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/lio2.467"],"URL":"https:\/\/doi.org\/10.1002\/lio2.467","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"assertion":[{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}