{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:09:03Z","timestamp":1790762943782,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To describe otologic dysfunction in patients with the novel SARS\u2010CoV\u20102.<\/jats:p>\n <\/jats:sec>\n \n Review Methods<\/jats:title>\n Search strategies acquired for each database included keywords. The keywords use were\u2014Otologic OR Vestibular OR Audiologic and COVID\u201019 OR Coronavirus OR SARS\u2010CoV\u20102. Resulting articles were imported into a systematic review software and screened for appropriateness.<\/jats:p>\n \n To be eligible for inclusion in the analysis, the studies and case reports should have met the following criteria:\n \n \n Description of otologic dysfunction in COVID\u201019 patients<\/jats:p>\n <\/jats:list-item>\n \n peer review<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n \n Studies were excluded if:\n \n \n the description of the specific dysfunction was inadequate<\/jats:p>\n <\/jats:list-item>\n \n there were no original case descriptions<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n Data that met the inclusion criteria was extracted and analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 62 articles were identified and screened, seven articles met the inclusion criteria and were analyzed. The articles were mainly case reports (5) with 2 case series. There were 28 patients in total identified with the largest study comprising 20 patients. All patients presented with hearing loss, 27 of whom had audiometry. Three patients had associated vestibular symptoms (vertigo, otalgia, and tinnitus).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n SARS\u2010CoV\u20102 is a probable cause of middle ear infections and sensorineural hearing loss, secondary to spread of the novel virus into the middle ear and related neural structures.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.498","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T14:08:39Z","timestamp":1605622119000},"page":"1192-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Otologic dysfunction in patients with\n COVID<\/scp>\n \u201019: A systematic review"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-2400","authenticated-orcid":false,"given":"Shivesh","family":"Maharaj","sequence":"first","affiliation":[{"name":"Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Department of Otolaryngology University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Bello Alvarez","sequence":"additional","affiliation":[{"name":"Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Department of Otolaryngology University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Mungul","sequence":"additional","affiliation":[{"name":"Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Department of Otolaryngology University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapila","family":"Hari","sequence":"additional","affiliation":[{"name":"Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Department of Internal Medicine University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.4030"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","DOI":"10.14639\/0392-100X-N0820","article-title":"Vertigo and hearing loss during the COVID\u201019 pandemic \u2013 is there an association?","author":"Karimi\u2010Galougahi M","year":"2020","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116832"},{"key":"e_1_2_7_5_1","unstructured":"WHO Official Updates Coronavirus Disease 2019.https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200121-sitrep-1-2019-ncov.pdf?sfvrsn=20a99c10_4. Accessed August 22 2020."},{"key":"e_1_2_7_6_1","unstructured":"World Health Organization (WHO). Coronavirus (COVID\u201019).2020.https:\/\/who.sprinklr.com\/. Accessed August 22 2020."},{"key":"e_1_2_7_7_1","first-page":"94","article-title":"Acute otitis media and respiratory virus infections","volume":"8","author":"Ruuskanen O","year":"1989","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.2.291"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.521"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2020.102487","article-title":"New type of corona virus induced acute otitis media in adult, 102487","volume":"41","author":"Fidan V","year":"2020","journal-title":"Am J Otolaryngol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102473"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28655"},{"key":"e_1_2_7_13_1","first-page":"11","article-title":"The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID\u201019) outbreak \u2013 an update on the status","volume":"7","author":"Hong CZ\u2010S","year":"2020","journal-title":"Mil Med Res"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_86_20"},{"key":"e_1_2_7_15_1","first-page":"145561320946902","article-title":"Hearing loss in SARS\u2010CoV\u20102: What do we know?","author":"Saniasiaya J","year":"2020","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/2331216514541361"},{"key":"e_1_2_7_17_1","unstructured":"COVID\u201019 Treatment Guidelines Panel.Coronavirus diseases 2019 (COVID\u201019) treatment guidelines. National Institutes of Health.https:\/\/www.covid19treatmentguidelines.nih.gov\/. Accessed August 20 2020."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0013164418823249"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.0780"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.05.034"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102483"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00122"},{"key":"e_1_2_7_23_1","first-page":"102513","article-title":"Comment on \u201chearing loss and COVID\u201019: a note","volume":"41","author":"Cure E","year":"2020","journal-title":"Am J Otolaryngol Head Neck Med Surg"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.06.023"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.498","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T14:48:53Z","timestamp":1693752533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/lio2.498"],"URL":"https:\/\/doi.org\/10.1002\/lio2.498","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}