{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:08:27Z","timestamp":1784081307459,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To estimate the overall and subgroup prevalence of otitis media with effusion (OME) in Africa, and identify setting\u2010specific predictors in children and adults.<\/jats:p><\/jats:sec>Methods<\/jats:title>PubMed, African Journals Online, African Index Medicus, Afrolib, SciELO, Embase, Scopus, Web of Science, The Cochrane Library, GreyLit and OpenGray were searched to identify relevant articles on OME in Africa, from inception to December 31st 2019. A random\u2010effects model was used to pool outcome estimates.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 38 studies were included, with 27 in meta\u2010analysis (40\u2009331 participants). The overall prevalence of OME in Africa was 6% (95% CI: 5%\u20107%; I<\/jats:italic>2<\/jats:sup> =\u200997.5%, P<\/jats:italic>\u2009<\u2009.001). The prevalence was 8% (95% CI: 7%\u20109%) in children and 2% (95% CI: 0.1%\u20103%) in adolescents\/adults. North Africa had the highest prevalence (10%; 95% CI: 9%\u201013%), followed by West and Southern Africa (9%; 95% CI: 7%\u201010% and 9%; 95% CI: 6%\u201012% respectively), Central Africa (7%; 95% CI: 5%\u201010%) and East Africa (2%; 95% CI: 1%\u20103%). There was no major variability in prevalence over the last four decades. Cleft palate was the strongest predictor (OR: 5.2; 95% CI: 1.4\u201018.6, P<\/jats:italic> = .02). Other significant associated factors were age, adenoid hypertrophy, allergic rhinitis in children, and type 2 diabetes mellitus, low CD4 count in adults.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>OME prevalence was similar to that reported in other settings, notably high\u2010income temperate countries. Health care providers should consider age, presence of cleft palate, adenoid hypertrophy and allergic rhinitis when assessing OME in children and deciding on a management plan. More research is required to confirm risk factors and evaluate treatment options.<\/jats:p><\/jats:sec>Level of Evidence<\/jats:title>3a<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.502","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T19:00:01Z","timestamp":1605639601000},"page":"1205-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Otitis media with effusion in Africa\u2010prevalence and associated factors: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-9910","authenticated-orcid":false,"given":"Emmanuel","family":"Choffor\u2010Nchinda","sequence":"first","affiliation":[{"name":"Department of Surgery and Specialties, Faculty of Health Sciences University of Buea Buea Cameroon"},{"name":"ENT Unit, Buea Regional Hospital Buea 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