{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:45:38Z","timestamp":1773359138797,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Recently, a novel host\u2010related index, the Host\u2010index (H\u2010index), including both inflammatory and nutritional markers, has been described and observed to stratify prognosis in patients with squamous cell carcinoma (SCC) of the oral cavity more accurately than other host\u2010related indexes This study aimed to investigate the prognostic performance of the H\u2010index using pretreatment blood tests in patients receiving up\u2010front surgery for SCC of the larynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study included a multicenter series of consecutive patients with SCC of the larynx diagnosed between 1 January 2009 and 31 July 2018, whose pretreatment blood tests were available and included the parameters necessary for the calculation of neutrophil to lymphocyte ratio (NLR) and the H\u2010index. Their association with disease\u2010free survival (DFS) and overall survival (OS) was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 231 patients were eligible for the present analysis (median [range] age, 68 [37\u201096] years; 191 [82.7%] men). The median follow\u2010up was 73\u2009months. In multivariable Cox proportional hazards regression models, increasing age (adjusted hazard ratio [aHR], 1.07 per year; 95% CI, 1.04\u20101.09), advanced pT stage (aHR\u00a0=\u00a01.71 95% CI: 1.07\u20102.71), and having close or positive surgical margins (aHR\u00a0=\u00a02.01; 95% CI: 1.21\u20103.33) were significantly associated with poor OS. Among blood parameters, a higher neutrophil count was a strong predictor of both worse DFS (aHR for recurrence\/death\u00a0=\u00a02.34; 95% CI: 1.24\u20104.40) and OS (aHR for death\u00a0=\u00a02.67; 95% CI: 1.51\u20104.71). Among inflammatory blood indexes, while NLR was not significantly associated with DFS or OS, patients with H\u2010index \u22658.37 showed a higher aHR for both recurrence\/death (2.82; 95% CI: 1.65\u20104.79) and death (2.22; 95% CI: 1.26\u20103.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the present study confirms the prognostic value of pretreatment H\u2010index, an easily measurable inflammatory and nutritional index, in patients with SCC of the larynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>III<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.603","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:33:06Z","timestamp":1624447986000},"page":"729-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic value of H\u2010index in patients surgically treated for squamous cell carcinoma of the larynx"],"prefix":"10.1002","volume":"6","author":[{"given":"Paolo","family":"Boscolo\u2010Rizzo","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, Section of Otolaryngology University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Zanelli","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, Section of Otolaryngology University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Giudici","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-2376","authenticated-orcid":false,"given":"Francesca","family":"Boscolo\u2010Nata","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology Ospedali Riuniti Padova Sud \"Madre Teresa Di Calcutta\"  Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cristalli","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology Ospedali Riuniti Padova Sud \"Madre Teresa Di Calcutta\"  Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-7333","authenticated-orcid":false,"given":"Alberto","family":"Deganello","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-1654","authenticated-orcid":false,"given":"Michele","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bossi","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Department of Medical Oncology ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Spinato","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology AULSS 2\u2014Marca Trevigiana  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Menegaldo","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology AULSS 2\u2014Marca Trevigiana  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Emanuelli","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology AULSS 2\u2014Marca Trevigiana  Treviso Italy"},{"name":"Department of Neurosciences, Section of Otolaryngology University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Otolaryngology University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Bandolin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Otolaryngology University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ciorba","sequence":"additional","affiliation":[{"name":"ENT Department University Hospital of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Pelucchi","sequence":"additional","affiliation":[{"name":"ENT Department University Hospital of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Lupato","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Azienda Ospedaliera \u201cS. Maria degli Angeli\u201d  Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Giacomarra","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Azienda Ospedaliera \u201cS. Maria degli Angeli\u201d  Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-2122","authenticated-orcid":false,"given":"Gabriele","family":"Molteni","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Otolaryngology University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Marchioni","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Otolaryngology University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-5035","authenticated-orcid":false,"given":"Pietro","family":"Canzi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pavia, IRCCS Policlinico \"San Matteo\" Foundation  Pavia 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