{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:36:47Z","timestamp":1782481007977,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Unilateral vocal cord paralysis may result from nerve compression by tumors or direct nerve injuries during tumor resections, which can cause dysphonia or dysphagia, and reduced quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This prospective, single\u2010group study aimed to investigate the effect of percutaneous injection laryngoplasty on voice and swallowing function in patients with cancer\u2010related unilateral vocal cord paralysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients underwent percutaneous injection laryngoplasty with hyaluronic acid under local anesthesia. Stroboscopy and videofluoroscopic swallowing study were conducted to evaluate the voice\u2010 and swallowing\u2010related outcome measures, respectively. The participants were evaluated before injection laryngoplasty, as well as after two weeks and three months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Injection laryngoplasty significantly improved the glottal gap, vocal fold position, Maximum Phonation Time, and Voice Handicap Index\u201010. Post\u2010hoc analysis using Bonferroni correction showed that the improvements occurred within two post\u2010treatment weeks and remained at three post\u2010treatment months. In the subgroup analysis, the patients who underwent injection laryngoplasty within 8\u2009weeks from onset showed significantly higher improvements in the videofluoroscopic dysphagia scale and swallowing function than the patients who received the procedure after 8\u2009weeks or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Percutaneous injection laryngoplasty improves glottal closure and voice in patients with cancer\u2010related unilateral vocal cord paralysis. Early injection laryngoplasty may lead to greater benefits on swallowing function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.618","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T10:54:19Z","timestamp":1626519259000},"page":"800-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of percutaneous injection laryngoplasty on voice and swallowing problems in <scp>cancer\u2010related<\/scp> unilateral vocal cord paralysis"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-9607","authenticated-orcid":false,"given":"Min\u2010Gu","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Physical Medicine and Rehabilitation Dong\u2010A University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-7542","authenticated-orcid":false,"given":"Han Gil","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-7717","authenticated-orcid":false,"given":"Eun\u2010Jae","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6666-6284","authenticated-orcid":false,"given":"Hyun Haeng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Konkuk University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2142-0472","authenticated-orcid":false,"given":"Seo Jung","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-4247","authenticated-orcid":false,"given":"Bhumsuk","family":"Keam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-4426","authenticated-orcid":false,"given":"Tae Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-7666","authenticated-orcid":false,"given":"Seong Keun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-7541","authenticated-orcid":false,"given":"Byung\u2010Mo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute on Aging, Seoul National University  Seoul Republic of Korea"},{"name":"National Traffic Injury Rehabilitation Hospital  Yangpyeong Republic of Korea"},{"name":"Neuroscience Research Institute, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.117714"},{"issue":"11","key":"e_1_2_8_3_1","first-page":"855","article-title":"Paralysis of the recurrent laryngeal nerve by an extracapsular thyroid adenoma","volume":"68","author":"Slomka W","year":"1989","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.05.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-014-0038-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0191-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2008.05.007"},{"key":"e_1_2_8_8_1","unstructured":"LogemannJ.Manual for the videofluorographic study of swallowing. Pro\u2010Ed;1993."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2020.44.1.1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2017.41.6.1019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9524-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9097-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_8_14_1","unstructured":"Association AS\u2010L\u2010H.National Outcomes Measurement System (NOMS): Adult speech\u2010language pathology user's guide;2003."},{"issue":"7","key":"e_1_2_8_15_1","first-page":"870","article-title":"The development and validation of a dysphagia\u2010specific quality\u2010of\u2010life questionnaire for patients with head and neck cancer: the MD Anderson dysphagia inventory","volume":"127","author":"Chen AY","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2013.37.4.479"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.10.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.4964509"},{"issue":"2","key":"e_1_2_8_21_1","first-page":"1","article-title":"Acoustic analysis of voice source dynamics","volume":"25","author":"Ananthapadmanabha T","year":"1984","journal-title":"STL\u2010QPSR"},{"issue":"4","key":"e_1_2_8_22_1","first-page":"50","article-title":"Measuring insufficient vocal fold closure during phonation","volume":"24","author":"Fritzell B","year":"1983","journal-title":"STL\u2010QPSR"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318137385e"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.177"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(97)80024-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-005-0531-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000204759.76865.39"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170701774901"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00395.2002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.09.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131809700822"},{"issue":"86","key":"e_1_2_8_33_1","first-page":"215","article-title":"Outcomes of autologous fat injection laryngoplasty in unilateral vocal cord paralysis","volume":"28","author":"Khadivi E","year":"2016","journal-title":"Iran J Otorhinolaryngol"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-09980-1"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.618","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T13:03:38Z","timestamp":1693314218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,17]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/lio2.618"],"URL":"https:\/\/doi.org\/10.1002\/lio2.618","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,17]]},"assertion":[{"value":"2021-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}