{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:16:31Z","timestamp":1790007391632,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oropharyngeal squamous cell carcinoma (OPSCC) treatment results in impaired swallowing and quality of life (QOL). We analyzed a cross\u2010section of advanced stage OPSCC patients treated with multimodal therapies at our Survivorship Clinic to investigate treatment factors associated with QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of patient\u2010reported outcomes (PROMs) after primary OPSCC treatment using AJCC seventh edition staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 73 patients were included (90.1% human papillomavirus positive [HPV+]). There were no QOL differences between robotic surgery with radiation <jats:bold>\u00b1<\/jats:bold>\u2009chemotherapy patients (n\u00a0=\u00a029) and those treated by radiation\u00a0<jats:bold>\u00b1<\/jats:bold>\u2009chemotherapy (n\u00a0=\u00a044). Radiation field analysis demonstrated significant correlations between increasing doses to larynx and contralateral parotid and submandibular gland and worse swallowing as measured by the Eating Assessment Tool\u201010 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In advanced, mostly HPV+, OPSCC, we did not find clinically significant differences between QOL PROMs between surgical and radiation\u00a0<jats:bold>\u00b1<\/jats:bold>\u2009chemotherapy treatment groups. This highlights the need for continued therapy de\u2010escalation along with improved interventions for treatment related toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.628","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T07:51:02Z","timestamp":1631778662000},"page":"983-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Quality of life after radiation and transoral robotic surgery in advanced oropharyngeal cancer"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-6806","authenticated-orcid":false,"given":"Thomas M.","family":"Kaffenberger","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Pittsburgh School of Public Health  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Pittsburgh School of Public Health  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Wasserman\u2010Wincko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan P.","family":"Zandberg","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Clump","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-4594","authenticated-orcid":false,"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-668X","authenticated-orcid":false,"given":"Marci L.","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Acute and Tertiary Care University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania 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