{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:15Z","timestamp":1760909055140},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Importance<\/jats:title><jats:p>The benefit of adjuvant radiation in surgically treated T1\u20102N1 oropharyngeal cancer without adverse pathologic features remains unclear<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare population\u2010level survival outcomes in surgically\u2010treated T1\u20102N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective population\u2010based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998\u20132011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Population\u2010level study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with T1\u20102N1 OPSCC treated with surgical resection and neck dissection with or without adjuvant radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention(s) for Clinical Trials or Exposure(s) for observational studies<\/jats:title><jats:p>The use of postoperative adjuvant radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome(s) and Measures<\/jats:title><jats:p>Overall and disease\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Radiation was utilized in 74% of patients and was positively associated with extracapsular extension and well\u2010differentiated histology. The use of radiation was associated with improved mean overall survival (124 v. 108 months, p=0.023) and a non\u2010significant increase in mean disease\u2010specific survival (138 v. 131 months, p=0.053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The use of adjuvant radiation is associated with improved survival in surgically\u2010treated T1\u20102N1 squamous cell carcinoma of the oropharynx with unknown HPV status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>IV<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.64","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T05:38:07Z","timestamp":1486100287000},"page":"57-62","source":"Crossref","is-referenced-by-count":6,"title":["The Benefit of Adjuvant Radiation in Surgically\u2010Treated T1\u20102 N1 Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"2","author":[{"given":"Marcus M.","family":"Monroe","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery, University of Utah School of Medicine Salt Lake City Utah U.S.A"},{"name":"Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City Utah U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke O.","family":"Buchmann","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery, University of Utah School of Medicine Salt Lake City Utah U.S.A"},{"name":"Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City Utah U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery, University of Utah School of Medicine Salt Lake City Utah U.S.A"},{"name":"Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City Utah U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying J.","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Utah School of Medicine Salt Lake City Utah U.S.A"},{"name":"Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City Utah U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Utah School of Medicine Salt Lake City Utah U.S.A"},{"name":"Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City Utah U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Hashibe","sequence":"additional","affiliation":[{"name":"Family and Preventative Medicine, Division of Public Health, University of Utah School of Medicine Salt Lake City Utah U.S.A"},{"name":"Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City Utah U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.2815"},{"key":"e_1_2_4_3_1","first-page":"507","article-title":"Epidemiology of oral\u2010cavity and oropharyngeal carcinomas: controlling","volume":"46","author":"Hashibe M","year":"2013","journal-title":"a tobacco epidemic while a human papillomavirus epidemic emerges. 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