{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:56:09Z","timestamp":1777611369779,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with primary hyperparathyroidism (PHPT) treated surgically occasionally have normalized calcium, but persistently high parathyroid hormone (PTH). We hypothesized that a possible explanation for this phenomenon is an underlying hyperplasia rather than adenoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort of patients who underwent parathyroidectomy for PHPT with biopsy of a normal\u2010appearing parathyroid gland were included. Cellularity level of each biopsy and of the adenoma's rim was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients were included. Of them, 19 (40%) had postoperative normocalcemia but elevated PTH. There was no correlation between cellularity either in the rim or of the normal\u2010appearing parathyroid gland and postoperative PTH. The postoperative high PTH group had higher preoperative PTH (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and larger adenomas (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High PTH levels after successful parathyroidectomy in patients with primary hyperparathyroidism do not appear to result from underlying hyperplasia. A possible alternative explanation is that these patients have a higher preoperative burden of disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.644","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:44:32Z","timestamp":1631148272000},"page":"1220-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High parathyroid hormone levels after parathyroidectomy for parathyroid adenoma are not related to the cellularity of the remaining glands"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0442-0339","authenticated-orcid":false,"given":"Rotem","family":"Sagiv","sequence":"first","affiliation":[{"name":"Joyce &amp; Irving Goldman Medical School Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha","family":"Delgado","sequence":"additional","affiliation":[{"name":"Pathology Unit Soroka University Medical Center  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Re'em","family":"Sadeh","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Soroka Medical Center  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagi","family":"Shashar","sequence":"additional","affiliation":[{"name":"Clinical Research Center of Soroka Medical Center  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merav","family":"Fraenkel","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Soroka University Medical Center  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenia M.","family":"Yegodayev","sequence":"additional","affiliation":[{"name":"Shraga Segal Department of Microbiology, Immunology, and Genetics Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Elkabets","sequence":"additional","affiliation":[{"name":"Shraga Segal Department of Microbiology, Immunology, and Genetics Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-892X","authenticated-orcid":false,"given":"Ben\u2010Zion","family":"Joshua","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Barzilai Medical Center  Ashkelon 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