{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:33:09Z","timestamp":1794270789595,"version":"4.9.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare serum levels of brain\u2010derived neurotrophic factor (BDNF) and neurofilament light (NfL) chain in normal individuals and patients with mild and moderate\u2010severe obstructive sleep apnea syndrome (OSAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 81 subjects referred to Otorhinolaryngology (Ear\u2010Nose\u2010Throat), Gazi University Faculty of Medicine, between 2017 and 2019. Based on the severity of OSAS, patients were divided into three groups: group 1 with mild OSAS (apnea\u2010hypopnea index [AHI] 5\u201015; n\u00a0=\u00a026), group 2 with moderate\u2010severe OSAS (AHI\u2009&gt;\u200915; n\u00a0=\u00a032), and group 3 with normal individuals (AHI scores &lt;\u20095; n\u00a0=\u00a023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum NfL and BDNF levels were evaluated together with the clinical data for all subjects. Significant differences were seen in the oxygen desaturation index (ODI), apnea index, hypopnea index, sleep efficiency, and NfL levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) between the three groups. In the moderate\u2010severe group, NfL levels showed a significant positive correlation with apnea index (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.389), hypopnea index (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.455), and ODI (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04;\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.362).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings clarify the pathophysiology of OSAS in cases of repetitive hypoxia and chronic neuronal damage. Based on our results, we recommend that in addition to BDNF, NfL should also be evaluated in different and larger patient cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.683","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T08:26:12Z","timestamp":1634804772000},"page":"1466-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The evaluation of serum brain\u2010derived neurotrophic factor and neurofilament light chain levels in patients with obstructive sleep apnea syndrome"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-3226","authenticated-orcid":false,"given":"Burak","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Gazi University Faculty of Medicine Ankara Turkey"},{"name":"Department of Medical Biochemistry Erci\u015f State Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"\u015eemsi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"\u0130riz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology (Ear\u2010Nose\u2010Throat) Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Sepici Din\u00e7el","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601113340207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3414"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.01.020"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227834"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17706"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.1.204"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2214"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00078"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.3.1245"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.055"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130419"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005108"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001723308"},{"key":"e_1_2_8_16_1","first-page":"1","article-title":"A simple role for BDNF in learning and memory?","volume":"3","author":"Cunha C","year":"2010","journal-title":"Front Mol Neurosci"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00935-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy192"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5510-07.2008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.55782\/ane-2005-1558","article-title":"Brain preconditioning and obstructive sleep apnea syndrome","volume":"65","author":"Brzecka A","year":"2005","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.184"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075091"},{"key":"e_1_2_8_23_1","unstructured":"American Academy of Sleep Medicine. 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